Lipid metabolism and carcinogenesis, cancer development

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Long, Jia;Zhang, Chan-Juan;Zhu, Neng;Du, Ke;Yin, Yu-Fang;...

通讯作者：

Qin, Li

作者机构：

[Du, Ke; Zhang, Chan-Juan; Liao, Duan-Fang; Long, Jia; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Zhu, Neng] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

[Yin, Yu-Fang] Southern Illinois Univ, Sch Med, Dept Neurosci & Pharmacol, Springfield, IL USA.

[Tan, Xi] Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada.

[Liao, Duan-Fang; Qin, Li] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha, Hunan, Peoples R China.

通讯机构：

[Qin, Li] H

Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Lipid;cancer development;cancer treatment;carcinogenesis;lipid metabolism

期刊：

American Journal of Cancer Research

ISSN：

2156-6976

年：

2018

卷：

期：

页码：

778-791

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270359, 81774130, 81670268]; Hunan Provincial Education DepartmentHunan Provincial Education Department [15A138, 16C1210, 15A141]; Hunan traditional Chinese Medicine Administration [201614]; Natural Science Foundation of Guangxi ProvinceNational Natural Science Foundation of Guangxi Province [2015GXNSFEA139003]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

摘要：

The disorder of lipid metabolism is pathologically linked to hyperlipidemia, lipid storage disease, obesity and other related diseases. Intriguingly, recent studies have revealed that lipid metabolism disorders play an important role in carcinogenesis and development as well, since they cause abnormal expression of various genes, proteins, and dysregulation of cytokines and signaling pathways. More importantly, lipid-lowering drugs and anti-lipid per-oxidation treatment have been showing their advantages in clinic, in comparison with other anti-cancer drugs with high toxicity. Thus, further el...

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Lipid metabolism and carcinogenesis, cancer development

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