期刊论文

中文

中国医院用药评价与分析

1672-2124

2023

23

12

1439-1445

10.14009/j.issn.1672-2124.2023.12.006

No.202205014138:湖南省卫健委课题项目

本校为第一机构

目的:通过生物信息学及分子对接技术,从细胞焦亡角度挖掘得到治疗湿热蕴结型盆腔炎性疾病后遗症(SPID)的天然药物成分,为湿热蕴结型SPID的治疗及新药的研发开拓新思路.方法:通过GEO数据库检索与SPID相关的符合筛选条件的数据集,归纳整理后对其进行limma差异分析获得SPID的差异表达靶点.通过GeneCards平台,以湿热蕴结型SPID的主症及次症为关键词进行检索,获得湿热蕴结型的靶点.通过中国知网、万方数据库和PubMed寻找细胞焦亡相关的靶点,三者合并取交集得到与细胞焦亡相关的湿热蕴结型SPID靶点.利用CMap平台对获得的靶点进行计算分析得到天然药物小分子,并通过中药系统药理学数据库与分析平台寻找...

OBJECTIVE:To explore the natural pharmaceutical components for the treatment of sequelae of pelvic inflammatory disease(SPID)of damp-heat accumulation type from the perspective of cell pyroptosis through bioinformatics and molecular docking technology,so as to probe into new ideas for the treatment of SPID of damp-heat accumulation type and research and development of new drugs.METHODS:Data related to SPID that met the screening conditions was retrieved through GEO database,and differential expression targets of SPID were obtained by limma differential analysis after summarization.Through the ...