期刊论文

Regulatory effect of Xiang A 1 and 2 on the T-lymphocyte subsets of immunodeficient mice

中文

医学研究生学报

1008-8199

2009

22

8

804-807

10.16571/j.cnki.1008-8199.2009.08.005

湖南省卫生厅中医药科研基金重大课题(批准号:6201)； 湖南省自然科学基金资助项目(批准号:06JJ2055)；

本校为第一机构

目的：为研究中药复方防治艾滋病的机制,探讨湘A1号、2号对免疫缺陷模型小鼠的T细胞亚群的影响。方法：经腹腔注射环孢菌素A建立以CD4^＋T细胞数目减少为主要特征的免疫缺陷小鼠模型。试验设正常对照组,模型对照组,阳性药物组,湘A1号低、中、高剂量观察组,湘A2号低、中、高剂量观察组,每组10只。灌胃给药,每次0.7 ml/只,2次/d,连续给药1周,最后一次给药后禁水、禁食8 h,取标本进行T细胞亚群检测。结果：与模型对照组比较,湘A1号中、高剂量能显著上调CD4^＋T细胞亚群的百分率（P〈0.01或P〈0.05）,低、中、高剂量组能下调CD8^＋T细胞亚群百分率（P〈0.01或P〈0.05）,调整CD4^＋/CD8^＋T细胞比值（...

Objective： To study the mechanism of the Chinese medicinal compound in the prevention and treatment on AIDS, and discuss the effects of the two Chinese medicinal compounds Xiang A1 and Xiang A2 on the T-lymphocyte subsets in the mouse model of immunodeficiency. Methods ： By intra- peritoneal injection of cyclosporine A, we established the immunodefieieney model in 80 mice with the main feature of reduced number of CD4^＋ T cells, and equally divided them into 8 groups ： model control, positive medication, low-dose Xiang A 1 （L-XA1）, medium...