期刊论文

中文

中医药导报

1672-951X

2003

9

9

45-48

10.13862/j.cnki.cn43-1446/r.2003.09.025

国家中医药管理局新药开发专项基金

本校为第一机构

目的:考察宫环止血片的长期毒性.方法:以蒸馏水作为对照,宫环止血片浸膏混悬液按5.88g生药/kg、17.64g生药/kg、52.92g生药/kg3个剂量组连续给大鼠灌胃6个月(25周),此时小、中、大剂量分别相当于临床剂量的10.69、32.07、96.22倍.结果:给药期及恢复性观察期(2周)大鼠饮食、活动、二便正常,毛泽光洁.与蒸馏水对照组比较,体重增长、血液学及血液生化指标、主要脏器系数、肉眼观察及镜下组织形态学观察均无明显差异或异常.结论:宫环止血片临床用药范围内长期服用基本安全无毒,且无明显的延迟毒性.

Objective: To study on the long-term toxicity of Gonghuanzhixue Pills. Methods: Contrasted with distilled water, extract suspension of Gonghuanzhixue Pills was constantly perfuse stomach in 3 groups of rat for 6 months with the dosage as 5.88g, 17.64g, 52.92g per kg respectively, corresponding 10.69, 32.07, 96.22 doubles as the clinical dosage. Results: The appetite, activity and excretion of rats were normal in the term of taking drugs and following observation for 2 weeks. Contrasted with the control group of distilled water, the increase of weight, hematology and blood biochemical parameter...