Effectiveness and Safety of Iguratimod Monotherapy or Combined With Methotrexate in Treating Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

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成果类型：

期刊论文

作者：

Ouyang, Dan;Ma, Yuan Zhi;Zou, Jie;Wang, Yong Long;Chen, Zheng;...

作者机构：

[Zou, Jie; Wang, Yong Long; Ma, Yuan Zhi; Chen, Zheng; Cao, Jian Zhong; Ouyang, Dan; Yang, Yu Ying; Li, Xin] Hunan Univ Chinese Med, Sch Chinese Med, Changsha, Peoples R China.

[Cao, Jian Zhong; Ouyang, Dan; Yang, Yu Ying; Li, Xin] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Chinese Med, Changsha, Peoples R China.

[Zou, Bin] Univ South China, Affiliated Changsha Cent Hosp, Gen Surg Dept, Changsha, Peoples R China.

语种：

英文

关键词：

rheumatoid arthritis1;systematic review2;meta-analysis3;methotrexate4;iguratimod5

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2022

卷：

页码：

2295

DOI：

10.3389/fphar.2022.911810

基金类别：

National Youth Science Foundation of China [81803993]; Research Fund of Hunan Province education Department [2020SK3034]

机构署名：

本校为第一机构

院系归属：

中医学院

摘要：

Objectives: We aimed to estimate the effectiveness and safety of iguratimod (IGU) monotherapy or in combination with methotrexate (MTX) in treating rheumatoid arthritis (RA) to provide an evidence-primarily-based foundation for clinical application. Methods: We conducted a systematic review of the meta-analysis using eight databases and two clinical trial websites searching for randomized controlled trials (RCTs) from conception to 15 March 2022, based on outcomes of patients with RA treated with IGU. The evidence quality assessment of primary outcomes was evaluated by the GRADE tool, and RevM...

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Effectiveness and Safety of Iguratimod Monotherapy or Combined With Methotrexate in Treating Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

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