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Qingqianliutianosides A-E: five new sweet dammarane triterpenoid glycosides derived from the leaves of Cyclocarya paliurus - identification, characterization and interactions with T1R2/T1R3 sweet taste receptors

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成果类型:
期刊论文
作者:
Guo, Tingsi;Yang, Yong;Liang, Ling;Huang, Qin;Hu, Qiqi;...
通讯作者:
Wang, Wei;Jian, YQ
作者机构:
[Xie, Qingling; Wang, Wei; Liang, Ling; Jian, Yuqing; Huang, Qin; Hu, Qiqi; Guo, Tingsi; Yuan, Hanwen; Yang, Yong] Hunan Univ Chinese Med, Innovat Mat Med Res Inst, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China.
[Chen, Guangyu] Hunan Univ Chinese Med, Engn Technol Res Ctr Med & Funct Food, Changsha, Peoples R China.
[Chen, Guangyu] Hunan Univ Chinese Med Changsha, Key Lab TCM Heart & Lung Syndrome Differentiat & M, Changsha, Peoples R China.
通讯机构:
[Wang, W; Jian, YQ ] H
Hunan Univ Chinese Med, Innovat Mat Med Res Inst, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China.
语种:
英文
关键词:
Cyclocarya paliurus;T1R2/T1R3 sweet taste receptors;dammarane triterpenoid glycosides;molecular docking
期刊:
Journal of the Science of Food and Agriculture
ISSN:
0022-5142
年:
2025
卷:
105
期:
2
页码:
1216-1227
基金类别:
National Natural Science Foundation of China; Changjiang Scholars Program in the Ministry of Education, People's Republic of China [T2019133]; Hunan Administration of Traditional Chinese Medicine [Xiangcai2021-105]; Excellent Youth Project of Hunan Provincial Department of Education [22B0388]; Project of Hunan Administration of Traditional Chinese Medicine [B2023143]; Opening Foundation of Hunan Key Laboratory of Natural Medicine Resources and Functions [2022ZYYGN03]; Opening Foundation of Traditional Chinese Medicine Processing Technology Inheritance Base of State Administration of Traditional Chinese Medicine [2022ZYPZ08]; Hunan Province Graduate Research Innovation Project [2023CX141]; [82174078]; [81803708]; [81874369]; [82074122]
机构署名:
本校为第一且通讯机构
院系归属:
药学院
中医诊断研究所
摘要:
BACKGROUND: Cyclocarya paliurus, as a new food resource, is utilized extensively in human and animal diets due to its bioactive compounds, health benefits, fi ts, and its highly prized sweet fl avor. This study aimed to investigate the sweet-taste ingredient of C. paliurus leaves. RESULTS: Five new dammarane triterpenoid glycosides were isolated and identified fi ed as qingqianliutianosides A-E - E (1-5) 1 - 5 ) by comprehensive spectroscopic data analysis and a single crystal X-ray diffraction experiment. Qingqianliutianoside A (1) 1 ) and qingqianliutianoside C (3), 3 ), present in relativel...

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