期刊论文

Influence of Sini Tang（SNT） on mRNA Expressions of Matrix Metalloproteinases-2,9 in Artherosclerosis Plaques of Rabbits

中文

中华中医药学刊

1673-7717

2013

31

2

367-369,后插3-后插4

10.13193/j.archtcm.2013.02.145.chenx.066

湖南省教育厅资助项目（06C629） 湖南省科技厅资助项目（2012SK3143）

本校为第一机构

目的:观察四逆汤对实验性高脂血症(HLP)合并动脉粥样硬化(AS)兔基质金属蛋白酶-2,9(MMP2,9)mRNA表达的影响,探讨四逆汤对兔动脉粥样硬化斑块稳定性的影响.方法:将60只新西兰大耳白兔,通过高脂饲料喂养及免疫损伤法建立兔HLP合并AS模型.然后随机分为6组,每组10只,即:空白组(空白对照组)、模型组(HLP合并AS模型组)、西药组(阿托伐他汀+HLP合并AS模型模型组)、SNT低剂量组(四逆汤低剂量+HLP合并AS模型模型组)、SNT中剂量组(四逆汤中剂量+HLP合并AS模型模型组)、SNT高剂量组(四逆汤高剂量+HLP合并AS模型组).运用原位杂交法检测兔动脉粥样硬化斑块中MMP-2,9mRNA的表达.结果:SNT各剂量组和西药均能抑制...

Objective：To observe the effect of SNT on mRNA expressions of matrix metalloproteinases -2,9 （MMP - 2, MMP -9）in artherosclerosis（AS） plaques of rabbits, and to explore the effect of SNT to the stability of artherosclerosis plaques of rabbits. Methods ： AS rabbit models were established by feeding high - fat diet. 60 New Zealandbig - eared rab- bits were divided into 6 groups ： HLP combined with different ways of Atorvastatin and three doses of SNT （ high, middle and low dose）, blank group（ blank control group）, model group （AS mode...