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Glycoside combinations of Buyang Huanwu decoction ameliorate atherosclerosis via STAT3, HIF-1, and VEGF

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成果类型:
期刊论文
作者:
Yan, Fanchen;Ding, Huang;Sun, Zhengji;Liu, Jingze;Li, Junxi;...
通讯作者:
Dan Zhou<&wdkj&>Wei Zhang
作者机构:
[Li, Junxi; Ding, Huang; Zhou, Dan; Zhang, Wei; Liu, Jingze; Yan, Fanchen] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Hunan, Peoples R China.
[Sun, Zhengji] Hunan Univ Chinese Med, Yueyang Tradit Chinese Med Hosp, Changsha 414021, Hunan, Peoples R China.
通讯机构:
[Dan Zhou; Wei Zhang] T
The Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine On Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>The Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine On Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China
语种:
英文
关键词:
Network pharmacology;Buyang Huanwu decoction;Glycoside combination;Atherosclerosis;Angiogenesis
期刊:
Naunyn-Schmiedeberg's Archives of Pharmacology
ISSN:
0028-1298
年:
2023
卷:
396
期:
6
页码:
1187-1203
基金类别:
Thanks to Professor Wei Zhang for his foundation support for this study. And this study was supported by the National Natural Science Foundation of China (81774032, 82174218), Natural Science Distinguished Young Scholars Foundation of Hunan Province (2020JJ2024), Key Scientific Research Project of Hunan Provincial Department of Education (19A374).
机构署名:
本校为第一且通讯机构
院系归属:
中西医结合学院
摘要:
Buyang Huanwu decoction (BYHWD) is a classical traditional prescription. Glycosides are effective extracts of BYHWD, which have been proven to protect blood vessels and prevent atherosclerosis (AS). However, the mechanism of glycosides in inhibiting abnormal angiogenesis in atherosclerosis is still unclear. The specific amygdalin (AG), paeoniflorin (PF), and astragaloside IV (ASV) contents in the BYHWD-containing serum were detected using mass spectrometry. Network pharmacology and molecular docking are used to screen the targets of glycosides for treating atherosclerosis. The predicted target...

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