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Cancer testis antigen SPAG9 is a promising marker for the diagnosis and treatment of lung cancer

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成果类型:
期刊论文
作者:
Ren, Biqiong;Wei, Xiaobin;Zou, Guoying;He, Junyu;Xu, Guofeng;...
通讯作者:
Yu, P
作者机构:
[Ren, Biqiong; Ma, Guoan; Wei, Xiaobin; Yu, Ping] Cent S Univ, Basic Med Coll, Dept Immunol, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.
[Ren, Biqiong; He, Junyu; Zhu, Haowen; Li, Yong; Zou, Guoying; Xu, Guofeng; Xu, Fei] Lab Second Peoples Hosp Hunan Prov, Changsha 410007, Hunan, Peoples R China.
[Ren, Biqiong; He, Junyu; Zhu, Haowen; Li, Yong; Zou, Guoying; Huang, Yiran; Xu, Guofeng; Xu, Fei] Hunan Univ Chinese Med, Dept Lab, Changsha 410007, Hunan, Peoples R China.
[Ma, Guoan] Tumor Hosp Hunan Prov, Changsha 410008, Hunan, Peoples R China.
通讯机构:
[Yu, P ] C
Cent S Univ, Basic Med Coll, Dept Immunol, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.
语种:
英文
关键词:
biological marker;cancer testis antigen;cancer testis antigen SPAG9;immunoglobulin G antibody;unclassified drug;autoantibody;immunoglobulin G;signal transducing adaptor protein;SPAG9 protein, human;tumor marker;adult;aged;antibody specificity;Article;cancer staging;cancer survival;controlled study;diagnostic value;female;gene expression regulation;human;human tissue;humoral immunity;immunoglobulin blood level;lung cancer;major clinical study;male;priority journal;protein expression;protein localization;survival time;upregulation;blood;case control study;gene expression;genetics;immunology;lung;lung tumor;metabolism;middle aged;mortality;pathology;squamous cell carcinoma;Adaptor Proteins, Signal Transducing;Adult;Aged;Autoantibodies;Biomarkers, Tumor;Carcinoma, Squamous Cell;Case-Control Studies;Female;Gene Expression;Humans;Immunoglobulin G;Lung;Lung Neoplasms;Male;Middle Aged
期刊:
ONCOLOGY REPORTS
ISSN:
1021-335X
年:
2016
卷:
35
期:
5
页码:
2599-2605
基金类别:
Hunan Province Science and Technology Fund [2009SK3092]; Key Clinical Specialized Fund of Hunan Second People's Hospital
机构署名:
本校为其他机构
摘要:
Cancer testis antigen sperm-associated antigen 9 (SPAG9) is highly expressed in many types of cancers. In the present study, to obtain a better understanding of the relevance of SPAG9 in cancer diagnosis and treatment, the expression of SPAG9 mRNA and protein in lung cancer specimens was evaluated by RT-PCR, western blotting and immunohistochemistry. ELISA was used to quantify the SPAG9 autoantibody in the peripheral blood of lung cancer patients. The results showed that the expression of SPAG9 mRNA and protein in the lung cancer tissues was significantly higher than that in the adjacent non-c...

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