期刊论文

Changes of β-endorphin in different tissue of the rabbits with incomplete trauma paraplegia by acupuncture

中文

中国中西医结合急救杂志

1008-9691

2003

10

5

282-284

10.3321/j.issn:1008-9691.2003.05.013

国家自然科学基金资助项目 （3 9970 92 6）；

本校为第一机构

目的:观察针灸对不完全性截瘫兔β-内啡肽(β-EP)影响的动态变化,探讨针灸对脊髓损伤修复的生化影响.方法:采用针刺督脉及神经干的方法治疗不完全性截瘫兔,取血液、垂体、损伤脊髓、下丘脑组织,测量在6 h、7 d、15 d时β-EP含量.结果:针灸1次(6 h)时β-EP含量即较模型组显著下降.针灸对血浆、垂体β-EP含量调整较快,6 h、7 d、15 d均呈阶段显著下降;下丘脑6 h与15 d比较出现显著差异;脊髓第7 d开始下降.结论:针灸通过加快β-EP降解弥散,阻断β-EP合成释放,迅速降低垂体β-EP分泌,减少血液循环中β-EP含量,从而减少与靶细胞的阿片受体结合,来达到对抗β-EP对脊髓继发损伤作用,加快修复过程.

Objective: To observe the effect of acupuncture on the change of βendorphin(βEP) in the rabbits with incomplete paraplegia, and to explore the biochemical effect of acupuncture to repair of damaged spinal cord. Methods: Acupuncture were applied to governor vessel and nerve trunk for treatment of the rabbits with incomplete paraplegia. The concentration of βEP in the plasma,pituitary,injuried spinal cord and hypothalamus of the rabbits was determined at 6 hours, 7 days and 15 days. Results: The concentration of βEP in rabbits after acupuntur...