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Effects of Astragalus Combined with Angelica on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice

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成果类型:
期刊论文
作者:
Li, Fei;Tang, Rong;Chen, Ling-Bo;Zhang, Ke-Sheng;Huang, Xiao-Ping;...
作者机构:
[Deng, Chang-Qing; Huang, Xiao-Ping] Hunan Univ Chinese Med, Mol Pathol Lab, Changsha 410208, Hunan, Peoples R China.
[Zhang, Ke-Sheng; Tang, Rong; Chen, Ling-Bo] Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Integrated, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
Astragalus;Angelica;bone marrow hematopoiesis suppression;hematopoietic growth factor (HGF);hematopoietic progenitor cell (HPC);chemical component
期刊:
Biological & Pharmaceutical Bulletin
ISSN:
0918-6158
年:
2017
卷:
40
期:
5
页码:
598-609
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473581, 81573875]
机构署名:
本校为第一机构
院系归属:
医学院
中西医结合学院
摘要:
Danggui Buxue Tang (DBT), a combination of Astragalus and Angelica at a 5 : 1 ratio, mainly promotes hematopoiesis. However, in the clinic, the combination ratio of Astragalus and Angelica to treat low hematopoietic function is not an absolute 5 : 1 ratio, suggesting that the herbs may promote hematopoiesis better after being combined at a certain range of ratios. The objective of this study is to investigate the effect of different ratio combinations of Astragalus and Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide (CTX) and to probe the interaction and mechanism...

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