Effects of Bushen-Yizhi formula on age-related inflammation and oxidative stress in senescence-accelerated mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hou, Xue-Qin;Song, Hou-Pan（宋厚盼）;Chen, Yun-Bo;Cheng, Shu-Yi;Fang, Shu-Huan;...

通讯作者：

Zhang, Ji-Guo;Wang, Qi

作者机构：

[Hou, Xue-Qin; Zhang, Ji-Guo] Taishan Med Coll, Inst Pharmacol, 619 Chang Cheng Rd, Tai An 271016, Shandong, Peoples R China.

[Song, Hou-Pan] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Chen, Yun-Bo; Cheng, Shu-Yi; Fang, Shu-Huan; Wang, Qi] Guangzhou Univ Chinese Med, Inst Clin Pharmacol, Design Measurement & Evaluat Clin Res Ctr, 12 Airport Rd, Guangzhou 510405, Guangdong, Peoples R China.

通讯机构：

[Zhang, Ji-Guo] T

[Wang, Qi] G

Taishan Med Coll, Inst Pharmacol, 619 Chang Cheng Rd, Tai An 271016, Shandong, Peoples R China.

Guangzhou Univ Chinese Med, Inst Clin Pharmacol, Design Measurement & Evaluat Clin Res Ctr, 12 Airport Rd, Guangzhou 510405, Guangdong, Peoples R China.

语种：

英文

关键词：

Bushen-Yizhi formula;aging;cognitive impairment;inflammation;oxidative stress;neuronal apoptosis

期刊：

Molecular Medicine Reports

ISSN：

1791-2997

年：

2018

卷：

期：

页码：

6947-6960

DOI：

10.3892/mmr.2018.8736

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81703901]; Doctoral Fund of Education Ministry of China [20134425110003]; Guangdong Provincial Major Science and Technology for Special Program of China [2012A080202017]; Shandong Province Natural Science Foundation of China [ZR2016HB56]; Foundation of Overseas Distinguished Taishan Scholars of Shandong Province; Collaborative Innovation Center for Research and Development of Traditional Chinese Medicine in Mount Tai

机构署名：

本校为其他机构

院系归属：

中医学院

摘要：

The present study aimed to investigate the possible effects and underlying molecular mechanism of Bushen-Yizhi formula (BSYZ), a traditional Chinese medicine, on age-related degeneration of brain physiology in senescence-accelerated mouse prone 8 (SAMP8) mice. SAMP8 mice (age, 6 months) were administered BSYZ (1.46, 2.92 and 5.84 g/kg/day) for 30 days. Morris water maze and step-down tests demonstrated that BSYZ significantly improved memory impairments in SAMP8 mice. In addition, BSYZ significantly enhanced the expression levels of peroxisome ...

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Effects of Bushen-Yizhi formula on age-related inflammation and oxidative stress in senescence-accelerated mice

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