Effects of Bushen-Yizhi formula on age-related inflammation and oxidative stress in senescence-accelerated mice

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成果类型：

期刊论文

作者：

Hou, Xue-Qin;Song, Hou-Pan（宋厚盼）;Chen, Yun-Bo;Cheng, Shu-Yi;Fang, Shu-Huan;...

通讯作者：

Zhang, JG;Wang, Q

作者机构：

[Hou, Xue-Qin; Zhang, Ji-Guo] Taishan Med Coll, Inst Pharmacol, 619 Chang Cheng Rd, Tai An 271016, Shandong, Peoples R China.

[Song, Hou-Pan] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Chen, Yun-Bo; Cheng, Shu-Yi; Fang, Shu-Huan; Wang, Qi; Wang, Q] Guangzhou Univ Chinese Med, Inst Clin Pharmacol, Design Measurement & Evaluat Clin Res Ctr, 12 Airport Rd, Guangzhou 510405, Guangdong, Peoples R China.

通讯机构：

[Wang, Q ] G

[Zhang, JG ] T

Taishan Med Coll, Inst Pharmacol, 619 Chang Cheng Rd, Tai An 271016, Shandong, Peoples R China.

Guangzhou Univ Chinese Med, Inst Clin Pharmacol, Design Measurement & Evaluat Clin Res Ctr, 12 Airport Rd, Guangzhou 510405, Guangdong, Peoples R China.

语种：

英文

关键词：

Bushen Yizhi formula;Chinese drug;cyclooxygenase 2;glial fibrillary acidic protein;glutathione peroxidase;immunoglobulin enhancer binding protein;interleukin 1beta;interleukin 6;malonaldehyde;peroxisome proliferator activated receptor gamma;protein bcl xl;superoxide dismutase;unclassified drug;bushen yizhi;cyclooxygenase 2;glial fibrillary acidic protein;glial fibrillary astrocytic protein, mouse;herbaceous agent;neuroprotective agent;peroxisome proliferator activated receptor gamma;Ptgs2 protein, mouse;animal experiment;animal model;animal tissue;apoptosis;Article;brain cortex;brain tissue;Chinese medicine;cognitive defect;controlled study;down regulation;drug efficacy;drug mechanism;drug megadose;enzyme activity;escape latency;hippocampus;histology;immunohistochemistry;inflammation;low drug dose;male;memory disorder;Morris water maze test;mouse;mRNA expression level;nonhuman;oxidative stress;passive avoidance;protein expression;reverse transcription polymerase chain reaction;senescence;senescence accelerated mouse;spatial learning;spatial memory;spatial memory test;step down test;TUNEL assay;animal;brain;brain chemistry;complication;cytology;drug effect;inflammation;maze test;memory;oxidative stress;physiology;premature aging;Aging, Premature;Animals;Apoptosis;Brain;Brain Chemistry;Cyclooxygenase 2;Drugs, Chinese Herbal;Glial Fibrillary Acidic Protein;Inflammation;Male;Maze Learning;Memory;Mice;Neuroprotective Agents;Oxidative Stress;PPAR gamma

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2018

卷：

期：

页码：

6947-6960

DOI：

10.3892/mmr.2018.8736

基金类别：

The present study was supported by the National Natural Science Foundation of China (grant no. 81703901), the Doctoral Fund of Education Ministry of China (grant no. 20134425110003), the Guangdong Provincial Major Science and Technology for Special Program of China (grant no. 2012A080202017), the Shandong Province Natural Science Foundation of China (grant no. ZR2016HB56), the Foundation of Overseas Distinguished Taishan Scholars of Shandong Province, and the Collaborative Innovation Center for Research and Development of Traditional Chinese Medicine in Mount Tai.

机构署名：

本校为其他机构

院系归属：

中医学院

摘要：

The present study aimed to investigate the possible effects and underlying molecular mechanism of Bushen-Yizhi formula (BSYZ), a traditional Chinese medicine, on age-related degeneration of brain physiology in senescence-accelerated mouse prone 8 (SAMP8) mice. SAMP8 mice (age, 6 months) were administered BSYZ (1.46, 2.92 and 5.84 g/kg/day) for 30 days. Morris water maze and step-down tests demonstrated that BSYZ significantly improved memory impairments in SAMP8 mice. In addition, BSYZ significantly enhanced the expression levels of peroxisome ...

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Effects of Bushen-Yizhi formula on age-related inflammation and oxidative stress in senescence-accelerated mice

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