β-Sitosterol attenuates anlotinib resistance in non-small cell lung cancer cells by inhibiting miR-181a-3p/SHQ1 signaling

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成果类型：

期刊论文

作者：

Wang, Li-huai;Sun, Yin-hui;Liu, Hua;Yang, Xiao;Wen, Zhi;...

通讯作者：

Tian, XF

作者机构：

[Wang, Li-huai] Hunan Univ Tradit Chinese Med, Grad Sch, Changsha, Hunan, Peoples R China.

[Wang, Li-huai] Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.

[Sun, Yin-hui] Hunan Univ Chinese Med, Sch Med, Changsha, Hunan, Peoples R China.

[Liu, Hua; Wen, Zhi; Yang, Xiao] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Oncol, Changsha, Hunan, Peoples R China.

[Tian, Xue-fei] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Tian, XF ] H

Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, 300 Bachelor Rd,Hanpu Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Anlotinib;SHQ1/UPR signaling;apoptosis;lung cancer;miR-181a-3p;proliferation;β-Sitosterol

期刊：

CHEMICAL BIOLOGY & DRUG DESIGN

ISSN：

1747-0277

年：

2024

卷：

103

期：

页码：

e14493-

DOI：

10.1111/cbdd.14493

基金类别：

Research Fund of Hunan University of Chinese Medicine (2020XJJJ033)

机构署名：

本校为第一机构

院系归属：

医学院

第一中医临床学院

中西医结合学院

研究生院

摘要：

A549 cells were treated with different concentrations of anlotinib to create anlotinib‐resistant A549 cells (A549/anlotinib cells). miR‐181a‐3p mimics were transfected into A549/anlotinib cells. Meanwhile, A549 and A549/anlotinib cells were treated with β‐sitosterol at different concentrations. Cell Counting Kit‐8 (CCK‐8) was used to measure cell proliferation. The apoptosis level was detected by flow cytometry. Real‐time fluorescence quantitative PCR was used to detect the expression of miR‐181a‐3p. miR‐181a‐3p interaction with H/A...

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β-Sitosterol attenuates anlotinib resistance in non-small cell lung cancer cells by inhibiting miR-181a-3p/SHQ1 signaling

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