Helicobacter pylori CagA promotes immune evasion of gastric cancer by upregulating PD-L1 level in exosomes

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Jinfeng;Deng, Rilin;Chen, Shuai;Deng, Shun;Hu, Qi;...

通讯作者：

Zuo, CH

作者机构：

[Peng, Mingjing; He, Zhuo; Wang, Jinfeng; Deng, Shun; Chen, Zhuo; Zuo, Chaohui] Hunan Canc Hosp, Translat Med Joint Res Ctr Liver Canc, Dept Gastroduodenal & Pancreat Surg, Lab Digest Oncol, Changsha 410013, Hunan, Peoples R China.

[Peng, Mingjing; He, Zhuo; Wang, Jinfeng; Deng, Shun; Chen, Zhuo; Zuo, Chaohui] Cent South Univ, Affiliated Canc Hosp, Clin Res Ctr Tumor Pancreaticobiliary Duodenal Jun, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.

[Deng, Rilin; Zhu, Haizhen] Hunan Univ, Inst Pathogen Biol & Immunol, Coll Biol, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Chen, Shuai; Chen, Zhuo; Zuo, Chaohui] Hunan Univ Chinese Med, Sch Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

[Xu, Biaoming; Hu, Qi; Chen, Zhuo; Zuo, Chaohui] Univ South China, Grad Sch, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zuo, CH ] H

Hunan Canc Hosp, Translat Med Joint Res Ctr Liver Canc, Dept Gastroduodenal & Pancreat Surg, Lab Digest Oncol, Changsha 410013, Hunan, Peoples R China.

Cent South Univ, Affiliated Canc Hosp, Clin Res Ctr Tumor Pancreaticobiliary Duodenal Jun, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.

Hunan Univ Chinese Med, Sch Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

Univ South China, Grad Sch, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Cancer;Gastroenterology;Microbiology

期刊：

iScience

ISSN：

2589-0042

年：

2023

卷：

期：

页码：

108414

DOI：

10.1016/j.isci.2023.108414

基金类别：

National Natural Science Foundation of China [82170192]; China Postdoctoral Science Foundation [2021M701151]

机构署名：

本校为通讯机构

院系归属：

中西医结合学院

摘要：

Cytotoxin-associated gene A (CagA) of Helicobacter pylori (Hp) may promote immune evasion of Hp-infected gastric cancer (GC), but potential mechanisms are still under explored. In this study, the positive rates of CagA and PD-L1 protein in tumor tissues and the high level of exosomal PD-L1 protein in plasma exosomes were significantly associated with the elevated stages of tumor node metastasis (TNM) in Hp-infected GC. Moreover, the positive rate of CagA was positively correlated with the positive rate of PD-L1 in tumor tissues and the level of PD-L1 protein in plasma exosomes, and high level ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Helicobacter pylori CagA promotes immune evasion of gastric cancer by upregulating PD-L1 level in exosomes

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问