Guggulsterone Promotes Nasopharyngeal Carcinoma Cells Exosomal Circfip1L1 to Mediate miR-125a-5p/VEGFA Affecting Tumor Angiogenesis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Ting;Zhao, Shunli;Tang, Sanyuan;Wang, Yongli;Wu, Ruoxia;...

通讯作者：

Zhang, X;Tian, XF

作者机构：

[Zhao, Shunli; Zhang, Xi; Zhou, Ting] Hunan Univ Tradit Chinese Med, Clin Med Coll, Changsha, Peoples R China.

[Zhao, Shunli; Zhang, Xi] Brain Hosp Hunan Prov, Dept Oncol, Changsha, Peoples R China.

[Tang, Sanyuan] South China Hosp Univ South China, Dept Oncol, Hengyang, Peoples R China.

[Wang, Yongli] Hunan Univ Tradit Chinese Med, Dept Oncol, Affiliated Hosp 1, Changsha, Peoples R China.

[Wu, Ruoxia] Hunan Univ Tradit Chinese Med, Sch Tradit Chinese Med, Changsha, Peoples R China.

通讯机构：

[Tian, XF ; Zhang, X ] H

Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Tradit Chinese Med, Med Coll Clin 1, Changsha, Peoples R China.

语种：

英文

关键词：

Guggulsterone;nasopharyngeal carcinoma;exosomal circFIP1L1;miR-125a-5p;VEGFA;angiogenesis.

期刊：

CURRENT MOLECULAR PHARMACOLOGY

ISSN：

1874-4672

年：

2023

卷：

期：

页码：

870-880

DOI：

10.2174/1874467216666230111112116

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

中西医结合学院

药学院

临床医学院

摘要：

Background: Nasopharyngeal carcinoma (NPC) is a usual head and neck malignancy. Guggulsterone (GS) has potential in cancer chemoprophylaxis and treatment, but its therapeutic effect on NPC is unknown. We aimed to explore whether GS could promote the secretion of exosomal circFIP1L1 from NPC cells and its regulatory mechanism.Methods: NPC tissues and adjacent tissues were collected from NPC patients. Human nasopharyngeal epithelial cell lines (NP69) and NPC lines (5-8F, CNE1, and HNE1) were used for in vitro experiments. HNE1 cells were treated ...

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Guggulsterone Promotes Nasopharyngeal Carcinoma Cells Exosomal Circfip1L1 to Mediate miR-125a-5p/VEGFA Affecting Tumor Angiogenesis

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