期刊论文

中文

中国中医药信息杂志

1005-5304

2005

12

8

15-17

10.3969/j.issn.1005-5304.2005.08.007

国家中医药管理局新药开发专项基金项目（DIX046B）；

本校为第一机构

目的探讨三七、茜草(SQ)复方治疗置铜宫内节育器(Cu-IUD)所致子宫异常出血的作用机理.方法制作家兔置Cu-IUD动物模型,以吲哚美辛作对照,观察SQ复方对置Cu-IUD家兔模型子宫匀浆中组织型纤溶酶原激活物(t-PA)活性的影响.结果置Cu-IUD家兔模型子宫匀浆中t-PA的含量增高(P＜0.01),经SQ复方治疗后与模型组比较有显著性差异(P＜0.01),说明SQ复方能减少家兔子宫匀浆中t-PA的含量,降低t-PA的活性.结论 SQ复方通过降低置Cu-IUD家兔子宫内膜局部的纤溶活性而达到止血的目的.

Objective To explore the mechanism of Radix Notoginseng and Radix Rubiae complexprescription for treating endometrorrhagia caused by Cu-IUD, to provide experimental foundation for the therapy of the disease. Methods We built up a animal model of Cu-IUD-wearing rabbits given SQ complex prescription in contrast with indomethacin by observing plasminogen activator, Resulta Cu-IUD raised the content of tissue-type-plasminogen activator （t-PA） of the animal model of Cu-IUD-wearing rabbits （P〈0.01）. SQ complex prescription decreased the content ...