An integrative pan cancer analysis of RET aberrations and their potential clinical implications

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成果类型：

期刊论文

作者：

Zhou, Lei;Li, Juanni;Zhang, Xiaofang;Xu, Zhijie;Yan, Yuanliang;...

通讯作者：

Hu, Kuan

作者机构：

[Zhou, Lei] Cent South Univ, Dept Anesthesiol, Xiangya Hosp 3, Changsha 410008, Hunan, Peoples R China.

[Xu, Zhijie; Li, Juanni] Cent South Univ, Xiangya Hosp, Dept Pathol, Changsha 410008, Hunan, Peoples R China.

[Yan, Yuanliang; Li, Juanni] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

[Zhang, Xiaofang] Hunan Univ Chinese Med, Ningxiang Peoples Hosp, Dept Burn, Changsha 410600, Hunan, Peoples R China.

[Zhang, Xiaofang] Hunan Univ Chinese Med, Ningxiang Peoples Hosp, Dept Plast, Changsha 410600, Hunan, Peoples R China.

通讯机构：

[Hu, Kuan] D

Department of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Hunan, Changsha, China

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2022

卷：

期：

DOI：

10.1038/s41598-022-17791-y

基金类别：

National Natural Science Foundation of China [82102743, 82103300]; Outstanding Postdoctoral Innovative Talents Foundation [2021RC2022]; Youth Science Foundation of Xiangya Hospital [2020Q07]

机构署名：

本校为其他机构

摘要：

RET (rearranged during transfection), encoding a tyrosine kinase receptor, is a novel therapeutic target for cancers. The aberrations of RET are commonly found in cancers. Here, we profiled a comprehensive genomic landscape of RET mutations, copy number variants (CNVs), co-occurrence of RET and its mRNA expression and methylation levels in pan cancer, paving the way to the development of new RET-targeted therapies in clinic. Analysis of RET somatic mutations, CNVs, co-occurrence, mRNA expression and methylation were performed among 32 cancer ty...

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An integrative pan cancer analysis of RET aberrations and their potential clinical implications

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