PURPOSE: To explore the related mechanisms of electroacupuncture at the "Siguan" acupoints in treating post-stroke depression (PSD). METHODS: Fifty male SD rats were randomly divided into the blank group, stroke group, PSD group, Siguan group and Bifidobacterium group, with 10 rats in each group. The Siguan group was given electroacupuncture at the bilateral "Hegu" (LI4) and "Taichong" (LR3), using the disperse-dense wave with a frequency of 2Hz/10Hz for 30minutes each time. The changes in depressive behaviors of rats were observed according to the sucrose consumption and the scores of the ope...