Disulfidptosis: a new target for central nervous system disease therapy

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成果类型：

期刊论文

作者：

Chang, Jing;Liu, Danhong;Xiao, Yuqi;Tan, Boyao;Deng, Jun;...

通讯作者：

Liao, J

作者机构：

[Tan, Boyao; Chang, Jing; Xiao, Yuqi] Hunan Univ Tradit Chinese Med, Coll Med, Changsha, Peoples R China.

[Liu, Danhong] Hunan Acad Chinese Med, Inst Clin Pharmacol Chinese Mat Med, Changsha, Peoples R China.

[Liu, Danhong] Hunan Acad Chinese Med, Hunan Prov Hosp Integrated Tradit Chinese & Wester, Affiliated Hosp, Changsha, Peoples R China.

[Deng, Jun] Hunan Prov Hosp Integrated Tradit Chinese & Wester, Dept Neurol, Changsha, Peoples R China.

[Liao, Jun; Mei, Zhigang; Liao, J] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha, Peoples R China.

通讯机构：

[Liao, J ] H

Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha, Peoples R China.

Hunan Univ Chinese Med, Med Coll, Vasc Biol Lab, Changsha, Peoples R China.

语种：

英文

关键词：

central nervous system diseases;disulfidptosis;therapy;thiol/disulfide;thiometabolism

期刊：

Frontiers in Neuroscience

ISSN：

1662-4548

年：

2025

卷：

页码：

1514253

DOI：

10.3389/fnins.2025.1514253

基金类别：

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by National Natural Science Foundation of China (81774033) and Natural Science Foundation of Hunan Province (2025JJ90019).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Disulfidptosis is a pathologic process that occurs under conditions of NADPH deficiency and excess disulfide bonds in cells that express high levels of SLC7A11. This process is caused by glucose deprivation-induced disulfide stress and was first described by cancer researchers. Oxidative stress is a hypothesized mechanism underlying diseases of the central nervous system (CNS), and disulfide stress is a specific type of oxidative stress. Proteins linked to disulfidptosis and metabolic pathways involved in disulfidptosis are significantly associated with diseases of the CNS (neurodegenerative d...

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Disulfidptosis: a new target for central nervous system disease therapy

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