Sensitive Detection of Argonaute2 by Triple-Helix Molecular Switch Reaction and Pyrene Excimer Switching

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成果类型：

期刊论文

作者：

Liao, Xianjiu;Pan, Jianbin;Zhang, Xiaolu*;Tang, Qianli*

通讯作者：

Tang, Qianli;Zhang, Xiaolu

作者机构：

[Tang, Qianli; Liao, Xianjiu] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

[Tang, Qianli; Liao, Xianjiu] Youjiang Med Univ Nationalities, West Guangxi Key Lab Prevent & Treatment High Inc, Baise 533000, Guangxi, Peoples R China.

[Pan, Jianbin; Liao, Xianjiu] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China.

[Pan, Jianbin; Liao, Xianjiu] Nanjing Univ, Sch Chem & Chem Engn, Collaborat Innovat Ctr Chem Life Sci, Nanjing 210023, Peoples R China.

[Zhang, Xiaolu] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Neurosurg, Wuxi 214000, Jiangsu, Peoples R China.

通讯机构：

[Tang, Qianli] H

[Tang, Qianli] Y

[Zhang, Xiaolu] N

Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

Youjiang Med Univ Nationalities, West Guangxi Key Lab Prevent & Treatment High Inc, Baise 533000, Guangxi, Peoples R China.

语种：

英文

期刊：

Australian Journal of Chemistry

ISSN：

0004-9425

年：

2020

卷：

期：

页码：

1074-1079

DOI：

10.1071/CH19485

机构署名：

本校为第一且通讯机构

院系归属：

中西医结合学院

摘要：

RNA interference (RNAi) is a powerful tool for silencing target genes in a variety of cells and has great therapeutic potential. It is triggered by small interfering RNAs (siRNAs) and by an RNA-binding protein (argonaute, Ago). In this manuscript, we designed a simple fluorescence sensor strategy for sensitive detection of argonaute2 (Ago2) based on the base pairing principle of Watson–Crick and Hoogsteen and the pyrene excimer switch. The sensing platform has extremely high sensitivity and a detection limit of 0.1 nM. It can be used to detec...

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Sensitive Detection of Argonaute2 by Triple-Helix Molecular Switch Reaction and Pyrene Excimer Switching

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