Homoharringtonine: mechanisms, clinical applications and research progress

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成果类型：

期刊论文

作者：

Wang, Wen;He, Lan;Lin, Ting;Xiang, Fulan;Wu, Yibin;...

通讯作者：

Zhou, Fangliang;He, YC

作者机构：

[Wang, Wen; Lin, Ting; Wu, Yibin; Xiang, Fulan] Hunan Univ Chinese Med, Grad Sch, Changsha, Peoples R China.

[He, Yingchun; Zhou, Fangliang; Lin, Ting; He, Lan; Zhou, FL] Hunan Univ Chinese Med, Hunan Prov Engn & Technol Res Ctr Prevent & Treatm, Changsha, Peoples R China.

[He, Yingchun; Zhou, Fangliang; Lin, Ting; He, Lan; Zhou, FL] Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha, Peoples R China.

[He, Yingchun; Zhou, Fangliang; Zhou, FL] Hunan Univ Chinese Med, Med Sch, Changsha, Peoples R China.

通讯机构：

[He, YC ; Zhou, FL] H

Hunan Univ Chinese Med, Hunan Prov Engn & Technol Res Ctr Prevent & Treatm, Changsha, Peoples R China.

Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha, Peoples R China.

Hunan Univ Chinese Med, Med Sch, Changsha, Peoples R China.

语种：

英文

关键词：

antitumor activity;cancer treatment;clinical applications;hematological disorders;homoharringtonine;pharmacological mechanisms

期刊：

FRONTIERS IN ONCOLOGY

ISSN：

2234-943X

年：

2025

卷：

页码：

1522273

DOI：

10.3389/fonc.2025.1522273

基金类别：

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (No. 82104941, 82305329), the Natural Sciences Funding Project of Hunan Province (No. 2022JJ30447, 2023JJ30449, 2023JJ40500) and The Science and Technology Innovation Program of Hunan Province (2024RC3202).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

研究生院

摘要：

Homoharringtonine is a natural alkaloid with significant pharmacological potential that has demonstrated promising efficacy in the treatment of hematological malignancies in recent years. This article systematically reviews the pharmacological mechanisms of Homoharringtonine, focusing on its key roles in inducing apoptosis, inhibiting cell cycle progression, and reducing cell migration and invasion. Additionally, HHT exhibits multiple biological activities, including immunomodulation, antiviral effects, and anti-fibrotic properties, with recent...

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