Systematic analysis of tRNA-derived small RNAs reveals therapeutic targets of Xuefu Zhuyu decoction in the cortexes of experimental traumatic brain injury

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成果类型：

期刊论文

作者：

Yang, Zhao-yu;Tang, Tao;Li, Peng-fei;Li, Xue-xuan;Wu, Yao;...

通讯作者：

Tao Tang

作者机构：

[Wang, Yang; Yang, Zhao-yu; Hu, Ming -rui; Li, Xue-xuan; Wu, Yao; Feng, Dan -dan; Tang, Tao] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Dept Integrated Tradit Chinese & Western Med, Changsha 410008, Peoples R China.

[Li, Peng-fei] Zhengzhou Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China.

[Dai, Feng] Cent South Univ, Xiangya Hosp, Emergency Med, Changsha 410008, Peoples R China.

[Zhang, Wei; Zheng, Fei] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Peoples R China.

[Wang, Yang; Yang, Zhao-yu; Hu, Ming -rui; Li, Xue-xuan; Wu, Yao; Feng, Dan -dan; Tang, Tao; Dai, Feng] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China.

通讯机构：

[Tao Tang] D

Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha 410008, China<&wdkj&>National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China

语种：

英文

关键词：

Traumatic brain injury;Xuefu Zhuyu Decoctions;tRNA-derived small RNAs;Transcriptome;Biomarker

期刊：

Phytomedicine

ISSN：

0944-7113

年：

2022

卷：

102

页码：

154168

DOI：

10.1016/j.phymed.2022.154168

基金类别：

National Natural Science Foundation of China [81973665, 81874425]; Outstanding Youth Foundation of Hunan Provincial Natural Science Foundation of China [2019JJ30042]; Innovation-Driven Project of Central South University [2020CX047]; Hunan Scientific Research Program of TCM [2021032]

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

BACKGROUND: Xuefu Zhuyu Decoction (XFZYD), a well-known traditional Chinese medicine prescription, has been widely used to treat traumatic brain injury (TBI). However, the underlying mechanisms involved in XFZYD therapy remain unclear. AIM OF THE STUDY: We explored new therapeutic targets of XFZYD in TBI by the tsRNA-sequencing (tsRNA-seq) method. MATERIAL AND METHODS: High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to assess the quality of XFZYD. Male Sprague-Dawley rats were randomly categorized into three groups: sham, TBI, and XFZYD. The protective eff...

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Systematic analysis of tRNA-derived small RNAs reveals therapeutic targets of Xuefu Zhuyu decoction in the cortexes of experimental traumatic brain injury

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