Steroid receptor RNA activator: Biologic function and role in disease

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成果类型：

期刊论文

作者：

Liu, Chan;Wu, Hong-Tao;Zhu, Neng;Shi, Ya-Ning;Liu, Zheng;...

通讯作者：

Qin, Li

作者机构：

[Liu, Chan; Zheng, Xi-Long; Shi, Ya-Ning; Ao, Bao-Xue; Liao, Duan-Fang; Liu, Zheng; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Liu, Chan; Ao, Bao-Xue; Liu, Zheng] Univ South China, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

[Wu, Hong-Tao] Cent S Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.

[Zhu, Neng] Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Cumming Sch Med, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Qin, Li] H

Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Long noncoding RNAs;Nuclear receptor;SRA;Transcriptional coactivator

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2016

卷：

459

页码：

137-146

DOI：

10.1016/j.cca.2016.06.004

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000946, 81270359, 81173047]; key projects of Hunan Provincial Education Department [15A138]; Natural Science Foundation of Guangxi ProvinceNational Natural Science Foundation of Guangxi Province [2015GXNSFEA139003]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

摘要：

Steroid receptor RNA activator (SRA) is a type of long noncoding RNA (lncRNA) which coordinates the functions of various transcription factors, enhances steroid receptor-dependent gene expression, and also serves as a distinct scaffold. The novel, profound and expanded roles of SRA are emerging in critical aspects of coactivation of nuclear receptors (NRs). As a nuclear receptor coactivator, SRA can coactivate androgen receptor (AR), estrogen receptor α (ERα), ERβ, progesterone receptor (PR), glucocorticoid receptor (GR), thyroid hormone rec...

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