Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells

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成果类型：

期刊论文

作者：

Zhang, Chanjuan;Zhu, Neng;Liu, Chan;Wu, Hongtao;Yin, Yantao;...

通讯作者：

Qin, Li

作者机构：

[Yin, Yantao; Liu, Chan; Shi, Yaning; Liao, Duanfang; Zhang, Chanjuan; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Yin, Yantao; Liu, Chan; Shi, Yaning; Liao, Duanfang; Zhang, Chanjuan; Qin, Li] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Zhu, Neng] Hunan Univ Chinese Med, Hosp 1, Dept Urol, Changsha 410208, Hunan, Peoples R China.

[Wu, Hongtao] Cent South Univ, Xiangya Hosp 2, Dept Urol, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Qin, Li] H

Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Cell motility;ERK signaling pathway;Renal cell carcinoma;Steroid receptor RNA activator

期刊：

International Journal of Molecular Medicine

ISSN：

1107-3756

年：

2020

卷：

期：

页码：

1765-1776

DOI：

10.3892/ijmm.2020.4730

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973668, 81774130, 81270359, 81000946, 81670268]; National Science Fund of Hunan Province for Distinguished Young Scholars [2018JJ1018]; Open Funds of State Key Laboratory of Oncology in South China [HN2019-07]; First-Class Discipline of Pharmaceutical Science of Hunan

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

摘要：

Renal cell carcinoma (RCC) has a high mortality rate among urological malignancies, and its underlying mechanisms remain unclear. Steroid receptor RNA coactivator (SRA) belongs to the long non-coding RNAs (lncRNAs) and has been demonstrated to be closely related to various types of cancer. In the present study, the decreased expression level of SRA was first confirmed in RCC tissues and cell lines by RT-qPCR. Using knockdown or overexpression systems, it was then found that SRA inhibited the proliferation of RCC cell lines and promoted their ap...

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Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells

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