Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells

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成果类型：

期刊论文

作者：

Zhang, Chanjuan;Zhu, Neng;Liu, Chan;Wu, Hongtao;Yin, Yantao;...

通讯作者：

Qin, L

作者机构：

[Yin, Yantao; Liu, Chan; Shi, Yaning; Qin, Li; Liao, Duanfang; Zhang, Chanjuan] Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Yin, Yantao; Liu, Chan; Shi, Yaning; Qin, Li; Liao, Duanfang; Zhang, Chanjuan] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Zhu, Neng] Hunan Univ Chinese Med, Hosp 1, Dept Urol, Changsha 410208, Hunan, Peoples R China.

[Wu, Hongtao] Cent South Univ, Xiangya Hosp 2, Dept Urol, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Qin, L ] H

Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

2 (2 amino 3 methoxyphenyl)chromone;breast cancer resistance protein;CD24 antigen;Hermes antigen;long untranslated RNA;mitogen activated protein kinase 1;mitogen activated protein kinase 3;octamer transcription factor 4;steroid receptor RNA activator;transcription factor;transcription factor Sox2;unclassified drug;long untranslated RNA;steroid receptor RNA activator;786-O cell line;A-498 cell line;apoptosis;Article;Caki-1 cell line;cancer stem cell;cancer tissue;cell invasion;cell proliferation;clinical article;controlled study;enzyme phosphorylation;epithelial mesenchymal transition;gene expression level;gene knockdown;gene overexpression;human;human cell;human tissue;MAPK signaling;migration inhibition;priority journal;protein function;real time polymerase chain reaction;renal cell carcinoma cell line;SN12C cell line;tumor invasion;biological model;cancer stem cell;cell cycle;cell motion;cell survival;down regulation;gene expression regulation;genetics;kidney tumor;metabolism;pathology;phosphorylation;renal cell carcinoma;tumor cell line;tumor invasion;Apoptosis;Carcinoma, Renal Cell;Cell Cycle;Cell Line, Tumor;Cell Movement;Cell Proliferation;Cell Survival;Down-Regulation;Epithelial-Mesenchymal Transition;Gene Expression Regulation, Neoplastic;Humans;Kidney Neoplasms;MAP Kinase Signaling System;Models, Biological;Neoplasm Invasiveness;Neoplastic Stem Cells;Phosphorylation;RNA, Long Noncoding

期刊：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISSN：

1107-3756

年：

2020

卷：

期：

页码：

1765-1776

DOI：

10.3892/ijmm.2020.4730

基金类别：

The present study was supported by grants from the National Natural Sciences Foundation of China to LQ (nos. 81973668, 81774130, 81270359 and 81000946), the National Natural Sciences Foundation of China to DL (no. 81670268), the National Science Fund of Hunan Province for Distinguished Young Scholars to LQ (no. 2018JJ1018), the Open Funds of State Key Laboratory of Oncology in South China to LQ (no. HN2019-07) and the First-Class Discipline of Pharmaceutical Science of Hunan. The present study was supported by grants from the National Natural Sciences Foundation of china to LQ (nos. 81973668, 81774130, 81270359 and 81000946), the National Natural Sciences Foundation of china to dL (no. 81670268), the National Science Fund of Hunan Province for distinguished Young Scholars to LQ (no. 2018JJ1018), the Open Funds of State Key Laboratory of Oncology in South china to LQ (no. HN2019-07) and the First-class discipline of Pharmaceutical Science of Hunan.

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

摘要：

Renal cell carcinoma (RCC) has a high mortality rate among urological malignancies, and its underlying mechanisms remain unclear. Steroid receptor RNA coactivator (SRA) belongs to the long non-coding RNAs (lncRNAs) and has been demonstrated to be closely related to various types of cancer. In the present study, the decreased expression level of SRA was first confirmed in RCC tissues and cell lines by RT-qPCR. Using knockdown or overexpression systems, it was then found that SRA inhibited the proliferation of RCC cell lines and promoted their ap...

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Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells

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