期刊论文

中文

中国中医药科技

1005-7072

2017

24

6

699-703

12A101:湖南省教育厅重点项目 :湖南中医药大学中医药临床基础重点学科资助

本校为第一机构

目的:观察清热解毒化浊片对肠源性内毒素血症肝损伤大鼠炎性因子TNF-α及小肠紧密连接蛋白-1(zonula occluden-1,ZO-1)(中文名称)的影响.方法:以高脂饲料和52％ Vol.白酒喂养建立肠源性内毒素血症肝损伤模型,造模成功后,随机分为治疗1组、治疗2组和模型组,模型组用白酒及蒸馏水灌胃、治疗1组用白酒及清热解毒化浊片悬浊液灌胃、治疗2组用蒸馏水及清热解毒化浊片悬浊液灌胃.经治疗1个月后检测肝功能(ALT、AST、ALP、GGT)及血浆内毒素水平,观察肝组织及小肠组织病理学改变,免疫组化法检测肝组织TNF-α及小肠组织ZO-1蛋白的表达.结果:与正常组比较,模型组血浆内毒素水平明显升高(P＜0.01),ALT、AST...

Objective:To observe the effect of Qingre Jiedu Huazhuo Tablet on hepatic tissue TNF-α and intestinal protein ZO-1 of liver injury rats with intestinal endotoxemia (IETM).Methods:Liver injury rat models with IETM were established by feeding with high-fat diet and 52％ Vol.liquor.The successful rat models were randomly divided into treatment group 1,treatment group 2 and model group.Liquor and distilled water were administered by gavage in model group,liquor and Qingre Jiedu Huazhuo Tablet suspension liquid were administered by gavage in treatm...