CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Shulan;Zhang, Hongning;Chen, Wen;Su, Na;Yuan, Changyue;...

通讯作者：

Hu, X;Xiang, SL

作者机构：

[Zhang, Hongning; Zhang, Jian; Chen, Wen; Hu, Xiang; Yuan, Changyue; Hu, X; Huang, Shulan; Su, Na] Hunan Normal Univ, Coll Life Sci, State Key Lab Dev Biol Freshwater Fish, Changsha 410081, Peoples R China.

[Chen, Wen] Hunan Univ Chinese Med, Med Sch, Key Lab Vasc Biol & Translat Med, Changsha 410208, Peoples R China.

[Xiang, Shuanglin; Su, Na] Hunan Normal Univ, Coll Life Sci, Engn Res Ctr Antibodies Expt Anim Hunan Prov, Changsha 410081, Peoples R China.

通讯机构：

[Xiang, SL ; Hu, X ] H

Hunan Normal Univ, Coll Life Sci, State Key Lab Dev Biol Freshwater Fish, Changsha 410081, Peoples R China.

Hunan Normal Univ, Coll Life Sci, Engn Res Ctr Antibodies Expt Anim Hunan Prov, Changsha 410081, Peoples R China.

语种：

英文

关键词：

tnfaip1;zebrafish;CRISPR;Cas9;embryonic development;RNA-seq

期刊：

Genes

ISSN：

2073-4425

年：

2023

卷：

期：

DOI：

10.3390/genes14051005

基金类别：

National Natural Science Foundation of China [81972642]; Hunan Provincial Natural Science Foundation of China [2021JJ30444]; Changsha City Natural Science Foundation of China [kq2007013]; Innovation and entrepreneurship fund for college students of the Hunan Normal University [2021118]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

TNF α-induced protein 1 (TNFAIP1) was first identified in human umbilical vein endothelial cells and can be induced by tumor necrosis factor α (TNFα). Early studies have found that TNFAIP1 is involved in the development of many tumors and is closely associated with the neurological disorder Alzheimer’s disease. However, little is known about the expression pattern of TNFAIP1 under physiological conditions and its function during embryonic development. In this study, we used zebrafish as a model to illustrate the early developmental expressi...

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CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development

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