期刊论文

Effect of Yin- Enriching and Eye -Brightening Pill on Expressions of Bcl -2 and p53 in Rat Retinal

中文

辽宁中医杂志

1000-1719

2017

44

5

1081-1083+1121

10.13192/j.issn.1000-1719.2017.05.059

国家自然科学基金项目（81303007/H2713） 全国名老中医药专家李传课传承工作室（国中医药人教发2013（47）号）

本校为第一机构

目的:通过观察滋阴明目丸对视网膜光损伤大鼠模型Bcl-2、p53表达的影响,探讨滋阴明目丸对视网膜光损伤大鼠模型的保护作用及治疗机制.方法:将60只Sprague-Dawley大鼠随机分为空白对照组、模型对照组、阳性对照组、滋阴明目丸低剂量组、滋阴明目丸中剂量组、滋阴明目丸高剂量组6组,每组10只.空白对照组不予处理,其余均建立视网膜光损伤大鼠模型,造模后第3天予以灌胃,连续15 d,其中滋阴明目丸低、中、高剂量组予以不同剂量滋阴明目丸灌胃,阳性对照组予以杞菊地黄丸灌胃.取大鼠眼球做免疫组化检测Bcl-2及p53的表达.结果:Bcl-2免疫组化结果:与空白对照组比较,模型对照组有统计学差异(P=0.025 ＜0.05...

Objective：By observing Yin- Enriching and Eye -Brightening Pill on retinal light damage rats＇ Bcl -2 and p53 expressions to discuss the protective effect and mechanism. Methods ： Sixty Sprague Dawley rats were randomly divided into blank control group, model control group, positive control group, Yin - Enriching and Eye - Brightening Pill low, middle and high dose groups,with 10 rats in each group. Do not deal with blank control group. The rest were to establish retinal light injury rat model. 3 days after modeling,the rats were given the me...