期刊论文

中文

辽宁中医杂志

1000-1719

2019

46

11

2426-2428+2462

10.13192/j.issn.1000-1719.2019.11.052

国家自然科学基金项目(81473616) 湖南省科技厅重点研发计划资助项目(2016DK2002) 湖南省教育厅重点项目(15A142) 湖南省中药粉体与创新药物省部共建国家重点实验室开放基金资助项目(ZYFT201503)。

本校为第一机构

目的:观察并探讨七芍方对自发性高血压大鼠尾静脉血压、心脏及肾脏血管形态学的影响,初步讨论其具体作用机制。方法:选取40只13周龄SPF级自发性高血压大鼠及10只相同周龄SPF级Wistar大鼠,按照完全随机对照原则,40只13周龄的自发性高血压大鼠分为模型组、中药干预组、对照组（本研究采用缬沙坦作为阳性对照药物）,其数量分别为10只、20只、10只,10只相同周龄Wistar大鼠作为空白对照组,在实验进行过程中每2周进行测量血压;第8周处死大鼠取出大鼠心脏组织及肾脏血管组织,进行形态学相关观察及研究。结果:中药干预组大鼠及对照组大鼠的血压与模型组大鼠对比有显著下降（P

Objective:To observe and investigate the effect of Qishao Prescription on the blood pressure of tail veins and cardiac and renal vascular morphology in spontaneously hypertensive rats and discuss its specific mechanism.Methods:A total of 4013-week-old spontaneously hypertensive rats and 10 Wistar rats at the same age were selected.According to the principle of complete randomization,the spontaneously hypertensive rats were divided into model group(group A,n=10).Chinese medicine intervention group(B group,n=20),control group(C group,n=10,Valsartan as a positive control drug).The Wistar rats wer...