期刊论文

Mechanism of Tianma Xiongling Zhixuan Tablet on Kidney Protection in Spontaneously Hypertensive Rats

中文

辽宁中医杂志

1000-1719

2020

47

8

190-194+225

10.13192/j.issn.1000-1719.2020.08.055

国家自然科学基金(81473616) 湖南省科技厅重点研发计划项目(2016DK2002) 湖南省教育厅重点项目(15A142) 湖南省中药粉体与创新药物省部共建国家重点实验室开放基金(ZYFT201503)

本校为第一机构

目的 观察并探讨天麻芎苓止眩片对自发性高血压大鼠肾脏保护效应,初步讨论其具体作用机制.方法 40只13周龄SPF级自发性高血压大鼠及10只相同周龄SPF级Wistar大鼠,按照完全随机对照原则,40只13周龄的自发性高血压大鼠分为模型组、(中药)中剂量组、(中药)低剂量组、对照组(本研究采用洛汀新作为阳性对照药物),每组数量均为10只,10只相同周龄Wistar大鼠作为空白对照组,在实验进行过程中进行血压及尿量监测,在实验第8周处死大鼠,抽取血清观察肾功能及炎症相关指标,并取其肾脏组织进行形态学相关观察及研究.结果 中药干预组大鼠及对照组大鼠的血压与模型组大鼠对比有显著下降(P＜0.05);中药干预组大鼠...

Objective To observe and explore the protective effect of Tianma Xiongling Zhixuan Tablet on spontaneously hypertensive rats and discuss its specific mechanism.Methods Forty 13-week-old SPF spontaneously hypertensive rats were randomly divided intomodel group,Chinese medicine middle dose group,Chinese medicine low dose group,control group(Lotintin was used as positive control drug in this study).Each group had 10,and 10 Wistar rats of the same age were used as the blank control group.The blood pressure and urine volume were monitored during the...