Dual role of insulin-like growth factor-1 in acetyl-CoA carboxylase-alpha activity in human colon cancer cells HCT-8: downregulating its expression and phosphorylation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Luo, Di-Xian;Peng, Xu-hong;Xiong, Yan;Liao, Duan-Fang;Cao, Deliang;...

通讯作者：

Li, Longjiang

作者机构：

[Luo, Di-Xian; Cao, Deliang] So Illinois Univ, Sch Med, Dept Microbiol Immunol & Cell Biol, Simmons Canc Inst, Springfield, IL 62702 USA.

[Li, Longjiang] Baoan Dist Peoples Hosp, Dept Urol Surg, Shenzhen 518101, Peoples R China.

[Luo, Di-Xian; Liao, Duan-Fang] Univ S China, Coll Pharmaceut & Life Sci, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Peng, Xu-hong] First Peoples Hosp, Dept Ultrasound Diag, Chenzhou City 423000, Peoples R China.

[Xiong, Yan] Guangzhou Med Univ, Dept Pharmacol, Guangzhou 510182, Guangdong, Peoples R China.

通讯机构：

[Li, Longjiang] B

Baoan Dist Peoples Hosp, Dept Urol Surg, 168 Longjing 2 Rd, Shenzhen 518101, Peoples R China.

语种：

英文

关键词：

Acetyl-CoA carboxylase-alpha;Insulin-like growth factor-1;Fatty acid/lipid synthesis;ERK1/2;AMPK;HCT-8 cells

期刊：

Molecular and Cellular Biochemistry

ISSN：

0300-8177

年：

2011

卷：

357

期：

1-2

页码：

255-262

DOI：

10.1007/s11010-011-0896-0

机构署名：

本校为其他机构

院系归属：

中医学院

药学院

摘要：

Insulin-like growth factor-1 (IGF-1) plays the role in cellular lipid synthesis and cell proliferation. However, the role of IGF-1 on the growth of colon cancer cell line HCT-8 is not clear. In this study, HCT-8 cells were exposed to IGF-1 at 0, 10, 50, or 100 ng/ml in serum-free medium. Fatty acid/lipid synthesis in HCT-8 cells was examined by 2-14C-acetate incorporation. HCT-8 cell growth and proliferation were determined by MTT assay and Trypan blue exclusive viable cell counting. We found that in serum starvation conditions, IGF-1 at 10-100...

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Dual role of insulin-like growth factor-1 in acetyl-CoA carboxylase-alpha activity in human colon cancer cells HCT-8: downregulating its expression and phosphorylation

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