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Gene Characteristics and Prognostic Values of m(6)A RNA Methylation Regulators in Nonsmall Cell Lung Cancer

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成果类型:
期刊论文
作者:
Li, Na;Chen, Xiaojuan;Liu, Yanhong;Zhou, Tieming;Li, Wei
作者机构:
[Zhou, Tieming; Li, Na; Liu, Yanhong] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Pathol, Changsha, Peoples R China.
[Chen, Xiaojuan] Maternal & Child Care Hosp, Dept Clin Lab, Changsha, Hunan, Peoples R China.
[Li, Wei] Cent South Univ, Dept Geriatr, Clin Lab, Xiangya Hosp, Changsha, Peoples R China.
语种:
英文
期刊:
Journal of Healthcare Engineering
ISSN:
2040-2295
年:
2021
卷:
2021
基金类别:
Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ50425, 2020JJ5909]; General Project of Hunan Provincial Education Department [18C1129]
机构署名:
本校为第一机构
院系归属:
医学院
第二中医临床医学院
摘要:
Background. N-6-methyladenosine (m(6)A) is the most common internal modi?cation present in mRNAs and long noncoding RNAs (lncRNAs), associated with tumorigenesis and cancer progression. However, little is known about the roles of m(6)A and its regulatory genes in nonsmall cell lung cancer (NSCLC). Here, we systematically explored the roles and prognostic significance of m(6)A-associated regulatory genes in NSCLC. Methods. The copy number variation (CNV), mutation, mRNA expression data, and corresponding clinical pathology information of 1057 NSCLC patients were downloaded from the cancer genom...

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