期刊论文

Effect of Jiawei Naotaifang on cerebral infarction area and level of estrogen of ovariectomized rats with cerebral ischemia and its correlation

中文

中国药理学通报

1001-1978

2018

34

3

428-432

10.3969/j.issn.1001-1978.2018.03.025

湖南省教育厅优秀青年科研项目（No 17B196） 湖南省教育厅一般科研项目（No 14C0857） 湖南省中医药管理局课题（No 201784）

本校为第一机构

目的探讨加味脑泰方对去势脑缺血大鼠脑梗死面积、脑组织病理学变化与血清雌激素水平的影响,分析脑梗死面积与雌激素水平的相关性。方法随机将SD大鼠分为假手术组、去势组、脑缺血组、模型组、药物组(雌激素组、加味脑泰方低、中、高剂量组) 。去势组、模型组、药物组大鼠制备去势模型,去卵巢术后11d,药物组给予药物灌胃3 d,然后模型组、脑缺血组、药物组大鼠制备局灶性脑缺血模型,24 h后取材,检测血清雌激素水平,TTC染色测量脑梗死面积,HE染色观察脑组织病理学变化情况。结果与脑缺血组比较,模型组大鼠脑梗死面积明显增大、雌激素水平更低,皮质和海马细胞坏死、核固缩更明显;与模型组比较,药物...

Aim To investigate the effects of Jiawei Naotaifang on cerebral infarction area, pathological changes of brain tissue and estrogen level of focal cerebral Iischemia in female ovariectomized rats, and correlation between estrogen levels and cerebral infarction area. Methods SD rats were randomly divided into sham operation group, ovariectomized group, cerebral ischemia group, model group, and drug groups ( estrogen group, Jiawei Naotaifang high dose group, Jiawei Naotaifang middle dose group, Jiawei Naotaifang low dose group ). The rats in the o...