Mitochondrial DNA mutations and essential hypertension

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ding, Yu;Xia, Bohou;Yu, Jinfang;Leng, Jianhang;Huang, Jinyu*

通讯作者：

Huang, Jinyu

作者机构：

[Ding, Yu; Leng, Jianhang] Nanjing Med Univ, Hangzhou Peoples Hosp 1, Cent Lab, Hangzhou 310006, Zhejiang, Peoples R China.

[Huang, Jinyu; Ding, Yu; Leng, Jianhang] Nanjing Med Univ, Affiliated Hangzhou Hosp, Hangzhou 310006, Zhejiang, Peoples R China.

[Xia, Bohou] Hunan Univ Chinese Med, Dept Pharm, Changsha, Hunan, Peoples R China.

[Yu, Jinfang] Nanjing Med Univ, Xiaoshan Peoples Hosp 1, Dept Cardiol, Hangzhou 310006, Zhejiang, Peoples R China.

[Huang, Jinyu] Nanjing Med Univ, Hangzhou Peoples Hosp 1, Dept Cardiol, Hangzhou 310006, Zhejiang, Peoples R China.

通讯机构：

[Huang, Jinyu] N

Nanjing Med Univ, Hangzhou Peoples Hosp 1, Dept Cardiol, 261 Huan Sha Rd, Hangzhou 310006, Zhejiang, Peoples R China.

语种：

英文

关键词：

Dysfunction;Essential hypertension;Mitochondria;Mutation

期刊：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISSN：

1107-3756

年：

2013

卷：

期：

页码：

768-774

DOI：

10.3892/ijmm.2013.1459

基金类别：

Ministry of Public Health of Zhejiang Province [2013KYA158]; Nanjing Medical University [2010NJMU011]; Hangzhou Bureau of Science and Technology [20120533Q03]; Specialized Research Fund for the Doctoral Program of Higher EducationSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20124323120004]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Essential hypertension (EH) is a frequent, chronic, age-related disorder, which remains a major modifiable risk factor for cardiovascular disease despite important advances in our understanding of its pathophysiology. Previous studies have noted a consistent maternal effect on blood pressure (BP). Consequently, mutations in mitochondrial DNA (mtDNA) have become an additional target of investigations on the missing BP heritability. Among these mutations, mt-transfer RNA (tRNA) is a hot mutational spot for pathogenic mutations associated with EH. Mutant mtDNA aggravates mitochondrial dysfunction...

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Mitochondrial DNA mutations and essential hypertension

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