Objective: To observe the effects of Zuogui Jiangtang Yishen Decoction (ZJYD) on blood glucose, blood lipids, renal function, serum inflammatory factors of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in MKR mice with diabetic nephropathy. Method: 8 weeks of MKR mice, which were dominant-negative insulin-like growth factor-1 receptor specifically targeted to the skeletal muscle were randomly divided into 5 groups: control group, high fat diet feed group, high-fat diet feed and mono-nephrectomy model group, ZJYD group, and...