Qingguang\'an-induced autophagy in TFs inhibits scar formation: A follow-up in vivo mechanistic investigation - 成果

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Qingguang'an-induced autophagy in TFs inhibits scar formation: A follow-up in vivo mechanistic investigation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Rong;Wang, Xian-jing;Chen, Shu;Huang, Yun;Yu, Juan

通讯作者：

Yu, J

作者机构：

[Yu, Juan; Chen, Shu; Hu, Rong; Wang, Xian-jing; Huang, Yun] Hunan Univ TCM, Affiliated Hosp 1, Changsha 410007, Peoples R China.

[Yu, Juan; Chen, Shu; Hu, Rong; Wang, Xian-jing; Huang, Yun] Hunan Univ TCM, Ophthalmol Dept, Changsha 410000, Peoples R China.

[Yu, Juan; Chen, Shu; Hu, Rong; Wang, Xian-jing; Huang, Yun] Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha 410208, Peoples R China.

[Yu, J; Yu, Juan] Hunan Univ TCM, Affiliated Hosp 1, Ophthalmol Dept, Changsha, Peoples R China.

通讯机构：

[Yu, J ] H

Hunan Univ TCM, Affiliated Hosp 1, Ophthalmol Dept, Changsha, Peoples R China.

语种：

英文

关键词：

Qingguang'an;Autophagy;Fibrosis;Scar formation;Glaucoma filtering surgery

期刊：

Journal of Traditional and Complementary Medicine

ISSN：

2225-4110

年：

2024

卷：

期：

页码：

173-181

DOI：

10.1016/j.jtcme.2023.10.002

基金类别：

National Natural Science Foundation of China (Inducing ef-fect of Qingguang'an on Autophagy of Tenon's Capsule Fibroblasts after Glaucoma Filtration Surgery) [81603665]; Training Program for Excellent Young Innovators of Changsha [kq2107014]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

Purpose: To investigate the mechanism by which Qingguang'an inhibits scar formation in rabbits administered glaucoma filtering surgery (GFS). Methods: Combined trabeculectomy was performed in 100 rabbits diagnosed with glaucoma, which were assigned to five groups, including the no surgery, surgery only, mitomycin C (MMC; positive control), Qingguang'an (experimental) and PBS (negative control) groups. The animals were followed up at postoperative days 1-28. Ultrastructure was observed under a transmission electron microscope (TEM). Real -Time Polymerase Chain Reaction (RT-PCR), Western blot, H...

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Qingguang'an-induced autophagy in TFs inhibits scar formation: A follow-up in vivo mechanistic investigation

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