Cyclopamine functions as a suppressor of benign prostatic hyperplasia by inhibiting epithelial and stromal cell proliferation via suppression of the Hedgehog signaling pathway

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yuan, Yi-Feng;Zhu, Wen-Xiong;Liu, Tao;He, Ju-Qiao;Zhou, Qing;...

通讯作者：

Yang, Jing

作者机构：

[Zhou, Qing; Zhu, Wen-Xiong; Yuan, Yi-Feng; Liu, Tao; He, Ju-Qiao; Zhou, Xing] Hunan Univ Chinese Med, Hosp 1, Dept Androl, Changsha 410007, Hunan, Peoples R China.

[Yang, Jing; Zhang, Xi] Hunan Univ Chinese Med, Coll Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Yang, Jing] H

Hunan Univ Chinese Med, Coll Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

cyclopamine;Hedgehog signaling pathway;benign prostatic hyperplasia;apoptosis;proliferation;epithelial cell;stromal cell

期刊：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISSN：

1107-3756

年：

2020

卷：

期：

页码：

311-319

DOI：

10.3892/ijmm.2020.4569

基金类别：

Clinical Medical Technological Innovation Guidance Project of Technological Innovation Guidance Plan in Hunan Province [2017SK50305]; Scientific Research Project of Traditional Chinese Medicine in Hunan Province [201832]; General Program of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81673984]; Construction Project of He Juqiao's National Traditional Chinese Medicine Expert Inheritance Studio

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

摘要：

Stromal‑epithelial interaction serves a pivotal role in normal prostate growth, as well as the onset of benign prostatic hyperplasia (BPH). The present study aimed to explore the role of cyclopamine in the proliferation and apoptosis of epithelial and stromal cells in rats with BPH by blocking the Hedgehog signaling pathway. Cyclopamine (an inhibitor of the Hedgehog signaling pathway) was administered in a rat model of BPH, and the expression of Ki67 (proliferation factor) was determined by immunohistochemistry. In addition, epithelial and str...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Cyclopamine functions as a suppressor of benign prostatic hyperplasia by inhibiting epithelial and stromal cell proliferation via suppression of the Hedgehog signaling pathway

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问