Glycosides from Buyang Huanwu Decoction inhibit atherosclerotic inflammation via JAK/STAT signaling pathway

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成果类型：

期刊论文

作者：

Fu, Xinying;Sun, Zhengji;Long, Qingyin;Tan, Wei;Ding, Huang;...

通讯作者：

Wei Zhang

作者机构：

[Ding, Huang; Tan, Wei; Zhang, Wei; Long, Qingyin; Fu, Xinying; Liu, Xiaodan] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Hunan, Peoples R China.

[Sun, Zhengji] Hunan Univ Chinese Med, Yueyang Tradit Chinese Med Hosp, Changsha 414021, Hunan, Peoples R China.

[Wu, Lu] Hunan Univ Chinese Med, Liuyang Tradit Chinese Med Hosp, Changsha 410399, Hunan, Peoples R China.

[Wang, Yang] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Key Lab Hunan Prov Liver Manifestat Tradit Chinese, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Wei Zhang] C

College of Integrated Chinese and Western Medicine, Key Laboratory of Hunan Provincial for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Hunan 410208, China

语种：

英文

关键词：

Atherosclerosis;BYHWD;Glycosides;Inflammation;JAK/STAT signaling pathway

期刊：

Phytomedicine

ISSN：

0944-7113

年：

2022

卷：

105

页码：

154385

DOI：

10.1016/j.phymed.2022.154385

基金类别：

National Natural Science Foundation of China [81774032, 82174218]; Natural Science Distin-guished Young Scholars Foundation of Hunan Province [2020JJ2024]; Natural Science Foundation of Hunan Province [2018JJ3391]; Key Scientific Research Project of Hunan Provincial Department of Educa-tion [19A374]

机构署名：

本校为第一机构

院系归属：

中西医结合学院

摘要：

BACKGROUND: Buyang Huanwu Decoction (BYHWD) has been used to treat or prevent cardiovascular disease. The prescription and its glycosides have the effects of protecting blood vessels, and resisting atherosclerosis. However, their protective mechanism of anti-atherosclerosis remains unclear. PURPOSE: This study aims to explore whether glycosides are the main effective components of BYHWD in anti-atherosclerotic inflammation and whether their mechanism is related to the classical JAK/STAT inflammatory signaling pathway. METHODS: UPLC-MSMS method was used to determine the main components of BYHWD...

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Glycosides from Buyang Huanwu Decoction inhibit atherosclerotic inflammation via JAK/STAT signaling pathway

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