Anti-Inflammatory Activity of Ezetimibe by Regulating NF-kappa B/MAPK Pathway in THP-1 Macrophages

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成果类型：

期刊论文

作者：

Qin, Li;Yang, Yun-Bo;Yang, Yi-Xin;Zhu, Neng;Li, Shun-Xiang;...

通讯作者：

Liao, Duan-Fang

作者机构：

[Li, Shun-Xiang; Yang, Yun-Bo; Zheng, Xi-Long; Liao, Duan-Fang; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Yang, Yun-Bo; Zhu, Neng] Cent S Univ, Xiang Ya Hosp 2, Changsha, Hunan, Peoples R China.

[Qin, Li] South China Univ, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

[Zhu, Neng] South China Univ, Affiliated Hosp 2, Hengyang, Hunan, Peoples R China.

[Yang, Yun-Bo; Yang, Yi-Xin] Western Univ, London Hlth Sci Ctr, Matthew Mailing Ctr Translat Transplantat Studies, London, ON, Canada.

通讯机构：

[Liao, Duan-Fang] H

Hunan Univ Chinese Med, 1 Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Ezetimibe;Inflammation;Mitogen-activated protein kinase;Nuclear factor kappa-light-chain-enhancer of activated B cells;Macrophage

期刊：

PHARMACOLOGY

ISSN：

0031-7012

年：

2014

卷：

期：

1-2

页码：

69-75

DOI：

10.1159/000357953

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000946, 81270359, 81173047, 12JJ5068]; construct program of the key discipline in Hunan province

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

Inflammation plays a crucial role in atherosclerosis. Monocytes/ macrophages are involved in the inflammatory process during atherogenesis. Here, we performed daily gavage of ezetimibe in apolipoprotein E-deficient mice fed with a high-fat diet and found that ezetimibe administration decreased the level of C-reactive protein significantly. To investigate the potential molecular mechanism, we employed microarray analysis on the cultured macrophages treated with Chol: M beta CD in the presence or absence of ezetimibe. We found that ezetimibe dramatically down-regulated the expression of the tumo...

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Anti-Inflammatory Activity of Ezetimibe by Regulating NF-kappa B/MAPK Pathway in THP-1 Macrophages

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