Biological evaluation of phytoconstituents from Polygonum hydropiper

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成果类型：

期刊论文

作者：

Xiao, Hong;Ravu, Ranga Rao;Tekwani, Babu L.;Li, Wei;Liu, Wen-Bin;...

通讯作者：

Wang, W;Li, XC

作者机构：

[Xiao, Hong; Wang, Wei; Li, Wei; Peng, Cai-Yun; Liu, Wen-Bin] Hunan Univ Chinese Med, Sch Pharm, Sino Luxemburg TCM Res Ctr, TCM & Ethnomed Innovat & Dev Lab, Changsha, Hunan, Peoples R China.

[Khan, Shabana I.; Li, Xing-Cong; Jacob, Melissa R.; Khan, Ikhlas A.; Ravu, Ranga Rao; Tekwani, Babu L.] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, Oxford, MS 38677 USA.

[Khan, Shabana I.; Li, Xing-Cong; Khan, Ikhlas A.; Tekwani, Babu L.] Univ Mississippi, Sch Pharm, Dept Biomol Sci, Oxford, MS 38677 USA.

[Cai, Xiong] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost & Therapeut Res Chine, Changsha, Hunan, Peoples R China.

通讯机构：

[Li, XC ] U

[Wang, W ] H

Hunan Univ Chinese Med, Sch Pharm, Sino Luxemburg TCM Res Ctr, TCM & Ethnomed Innovat & Dev Lab, Changsha, Hunan, Peoples R China.

Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, Oxford, MS 38677 USA.

Univ Mississippi, Sch Pharm, Dept Biomol Sci, Oxford, MS 38677 USA.

语种：

英文

关键词：

2 desoxy 4 epi pulchellin;3,7 dihydroxy 5,6 dimethoxyflavone;6,6' ((1alpha,2alpha,3beta,4beta) 2,4 diphenylcyclobutane 1,3 diyl)bis(4 methoxy 2h pyran 2 one);aniba dimer A;cardamomin;demethoxyyangonin;eflornithine;isalpinin;isorhamnetin;ketopinoresinol;peroxisome proliferator activated receptor;Persicaria hydropiper extract;pinosylvin;plant extract;sitosterol;unclassified drug;vanicoside B;vanicoside E;vanicoside F;antiinfective agent;antimalarial agent;antitrypanosomal agent;cardamonin;chalcone derivative;cinnamic acid derivative;gamma-sitosterol;nonsteroid antiinflammatory agent;peroxisome proliferator activated receptor gamma;plant extract;plant medicinal product;sitosterol derivative;vanicoside B;antiinflammatory activity;antimalarial activity;antimicrobial activity;antiprotozoal activity;Article;controlled study;cytotoxicity assay;drug isolation;drug screening;IC50;IC90;nonhuman;Persicaria hydropiper;phytochemistry;resazurin assay;structure activity relation;Trypanosoma brucei;chemical structure;chemistry;drug effects;genetics;microbial sensitivity test;Polygonum;preclinical study;procedures;Trypanosoma brucei brucei;Anti-Infective Agents;Anti-Inflammatory Agents, Non-Steroidal;Antimalarials;Chalcones;Cinnamates;Drug Evaluation, Preclinical;Microbial Sensitivity Tests;Molecular Structure;Phytochemicals;Plant Extracts;Polygonum;PPAR gamma;Sitosterols;Trypanocidal Agents;Trypanosoma brucei brucei

期刊：

Natural Product Research

ISSN：

1478-6419

年：

2017

卷：

期：

页码：

2053-2057

DOI：

10.1080/14786419.2016.1269094

基金类别：

This work were supported by the Education Department of Hunan Province [grant number 13k077]; Hunan State Key Laboratory of Chinese Medicine Powder and Medicine Innovation [grant number 201403]; Pharmaceutical Key Discipline Open Funded Projects of HUCM [grant number 07]; China Scholarship Council.

机构署名：

本校为其他机构

院系归属：

中医学院

药学院

摘要：

Fourteen compounds including vanicoside B (1), vanicoside F (2), vanicoside E (3) and 5,6-dehydrokawain (4), aniba-dimer-A (5), 6,6′-((1α,2α,3β,4β)-2,4-diphenylcyclobutane-1,3-diyl)bis(4-methoxy-2H-pyran-2-one) (6), (+)-ketopinoresinol (7), isorhamnetin (8), 3,7-dihydroxy-5,6-dimethoxy-flavone (9), isalpinin (10), cardamomin (11), pinosylvin (12), 2-desoxy-4-epi-pulchellin (13) and β-sitosterol (14) were isolated from dichloromethane-soluble portion of Polygonum hydropiper. By using Alamar blue assay, compounds 2, 7, 8, 11 and 12 were fou...

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Biological evaluation of phytoconstituents from Polygonum hydropiper

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