期刊论文

Effect of acupuncture technique of Tiaoxin Tongdu on learning-memory ability and expressions of hippocampal VEGF and Ang-1 in rats with vascular dementia

中文

中国针灸

0255-2930

2020

40

10

1108-1112

10.13703/j.0255-2930.20190821-0008

国家自然科学基金资助项目:81874508 湖南省科技计划项目:2015JJ4105。

本校为第一机构

目的:观察“调心通督”针刺法对血管性痴呆(VD)大鼠学习记忆能力及海马组织血管内皮生长因子(VEGF)、血管生成素-1(Ang-1)蛋白表达的影响,探讨“调心通督”针刺法治疗VD的作用机制。方法:24只雄性SD大鼠行Morris水迷宫实验后随机分为假手术组、模型组、西药对照组和调心通督针刺组,每组6只。模型组、西药对照组、调心通督针刺组大鼠采用双侧颈总动脉永久性结扎法复制VD模型。造模成功次日开始干预,调心通督针刺组选取“百会”“神庭”“水沟”“大椎”“风府”“命门”“内关”“大陵”“劳宫”进行针刺干预,每次30 min;西药对照组予尼莫地平溶液(0.0625 g/kg)灌胃,均每日1次,共干预2周。造模前...

Objective To observe the effect of acupuncture technique of Tiaoxin Tongdu on learning-memory ability and expressions of hippocampal vascular endothelial growth factor(VEGF)and angiogenin-1(Ang-1)in rats with vascular dementia(VD), and to explore the mechanism of acupuncture technique of Tiaoxin Tongdu for VD. Methods A total of 24 male SD rats were randomly divided into a sham operation group, a model group, a medication group and an acupuncture group after Morris water maze test, 6 rats in each group. VD model was established by permanent ligation of bilateral common carotid arteries in the ...