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The role of the Notch signalling pathway in the pathogenesis of ulcerative colitis: from the perspective of intestinal mucosal barrier

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成果类型:
期刊论文
作者:
Ning, Hang;Liu, Jiemin;Tan, Jiaqian;Yi, Mengni;Lin, Xiaoyuan
通讯作者:
Lin, XY
作者机构:
[Ning, Hang; Yi, Mengni] Hunan Univ Chinese Med, Sch Tradit Chinese Med, Changsha, Peoples R China.
[Liu, Jiemin] Guizhou Prov Peoples Hosp, Guiyang, Peoples R China.
[Tan, Jiaqian] Hunan Univ Chinese Med, Med Sch, Changsha, Peoples R China.
[Lin, XY; Lin, Xiaoyuan] Hunan Univ Chinese Med, Hosp 1, Changsha, Peoples R China.
通讯机构:
[Lin, XY ] H
Hunan Univ Chinese Med, Hosp 1, Changsha, Peoples R China.
语种:
英文
关键词:
Notch;mucosal barrier;review;signalling pathway;ulcerative colitis
期刊:
Frontiers in Medicine
ISSN:
2296-858X
年:
2024
卷:
10
页码:
1333531
基金类别:
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (82060850), the High-Level Innovative Talents Project of Guizhou Province, China [Qiankehe Platform Talents (2020)6016-2], and Hunan Province College Students’ Innovation and Entrepreneurship Training Program, China (S202310541013).
机构署名:
本校为第一机构
院系归属:
医学院
第一中医临床学院
摘要:
Ulcerative colitis is a common digestive disorder worldwide, with increasing incidence in recent years. It is an urgent problem to be solved, as it seriously affects and threatens the health and life of the global population. Studies have shown that dysfunction of the intestinal mucosal barrier is a critical pathogenic factor and molecular basis of ulcerative colitis, and some scholars have described it as a "barrier organ disease." While the Notch signalling pathway affects a series of cellular processes, including proliferation, differentiation, development, migration, and apoptosis. Therefo...

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