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Decoration of copper nanoparticles (Cu2O NPs) over chitosan-guar gum: Its application in the Sonogashira cross-coupling reactions and treatment of human lung adenocarcinoma

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成果类型:
期刊论文
作者:
Cheng, Xiongtao;Hemmati, Saba;Pirhayati, Mozhgan;Zangeneh, Mohamad Mehdi;Veisi, Hojat
通讯作者:
Veisi, H;Pirhayati, M
作者机构:
[Cheng, Xiongtao] Hunan Univ Chinese Med, Grad Sch, Changsha 410208, Hunan, Peoples R China.
[Hemmati, Saba; Veisi, Hojat] Payame Noor Univ, Dept Chem, Tehran, Iran.
[Pirhayati, Mozhgan] Malayer Univ, Fac Sci, Dept Appl Chem, Malayer, Iran.
[Zangeneh, Mohamad Mehdi] Ilam Univ Med Sci, Biotechnol & Med Plants Res Ctr, Ilam, Iran.
通讯机构:
[Pirhayati, M ] M
[Veisi, H ] P
Payame Noor Univ, Dept Chem, Tehran, Iran.
Malayer Univ, Fac Sci, Dept Appl Chem, Malayer, Iran.
语种:
英文
关键词:
Chitosan-guar gum;Copper (I) oxide nanoparticles;Lung cancer;PI3K/AKT/mTOR signaling pathway;Sonogashira coupling
期刊:
International Journal of Biological Macromolecules
ISSN:
0141-8130
年:
2025
卷:
305
期:
Pt 1
页码:
141122
基金类别:
CRediT authorship contribution statement Xiongtao Cheng: Writing – review & editing, Methodology, Investigation, acquisition. Saba Hemmati: Methodology, Investigation, acquisition. Mozhgan Pirhayati: Writing – original draft, Supervision, Methodology, Investigation. Mohamad Mehdi Zangeneh: Writing – review & editing, Writing – original draft, Methodology, Formal analysis. Hojat Veisi: Writing – review & editing, Writing – original draft, Supervision, Methodology, Investigation.
机构署名:
本校为第一机构
院系归属:
研究生院
摘要:
This study outlines the sustainable synthesis of hybrid biopolymer hydrogels supported with octahedral Cu 2 O nanoparticles (NPs), alongside their biological assessments and characterizations. A composite hydrogel made of chitosan and guar gum (CS-GG) was employed as a template for the environmentally friendly synthesis of nanoparticles. Leveraging their electron-rich functional groups, the biopolymers acted as stabilizing agents for the Cu 2 O NPs and as green reductants, facilitating the reduction of copper ions. The material's physicochemica...

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