SUMMARY. To evaluate the potential of sinomenine-cyclophosphamide interaction and to reveal the mechanism, male Sprague-Dawley rats were treated with the single administration of sinomenine or cyclophosphamide or the co-administration of two drugs with six of each. The pharmacokinetics and corresponding parameters were analyzed to evaluate the pharmacokinetic interaction between sinomenine and cyclophosphamide. In vitro assessment was conducted in rat liver microsomes, which estimated the metabolic stability and CYP2C19 activity. Sinomenine sig...
