Sitafloxacin pharmacokinetics/pharmacodynamics against multidrug-resistant bacteria in a dynamic urinary tract infection in vitro model

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成果类型：

期刊论文

作者：

Guo, Siwei;Li, Xin;Li, You;Tong, Huan;Wei, Minji;...

通讯作者：

Xin Li

作者机构：

[Tian, Miaomei; Tong, Huan; Guo, Siwei; Xu, Bing; Li, You; Li, Xin; Yan, Bingqian] Third Hosp Changsha, Changsha, Hunan, Peoples R China.

[Tong, Huan; Guo, Siwei; Xu, Bing; Li, Xin] Inst Clin Applicat Antibiot, Changsha, Hunan, Peoples R China.

[Tian, Miaomei; Li, You; Yan, Bingqian] Hunan Univ Chinese Med, Grad Sch, Changsha, Hunan, Peoples R China.

[Wei, Minji] Peking Univ, Hosp 1, Inst Clin Pharmacol, Beijing, Peoples R China.

[Shao, Jing] Nanjing Yoko Pharmaceut Co Ltd, Nanjing, Peoples R China.

通讯机构：

[Xin Li] T

The Third Hospital of Changsha , Changsha, Hunan , China<&wdkj&>Institute of Clinical Application of Antibiotics , Changsha, Hunan , China

语种：

英文

期刊：

Journal of Antimicrobial Chemotherapy

ISSN：

0305-7453

年：

2023

卷：

期：

页码：

141-149

DOI：

10.1093/jac/dkac365

基金类别：

Technology Plan Project for "Changsha Anti-Infective Drugs Engineering Technology Research Center" [kq1801120]; Hunan Provincial Science and Technology Department Foundation, China [2016SK4008, 2020SK52901]

机构署名：

本校为其他机构

院系归属：

研究生院

摘要：

OBJECTIVES: Sitafloxacin is one of the newer generation fluoroquinolones with highly active against multidrug-resistant (MDR) bacteria. Our objectives were to identify the sitafloxacin pharmacokinetic/pharmacodynamic (PK/PD) index and breakpoints against MDR isolate in the urinary tract infection model. METHODS: Forty-eight MDR isolates underwent sitafloxacin and levofloxacin microdilution susceptibility testing. A 24 h in vitro model was established that simulated the healthy subjects urodynamics of sitafloxacin fumarate injection. Ten MDR is...

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Sitafloxacin pharmacokinetics/pharmacodynamics against multidrug-resistant bacteria in a dynamic urinary tract infection in vitro model

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