DNase-targeted natural product screening based on a sensitive and selective DNase i detecting system

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhao, Chuan;Chen, Yanjiao;Fang, Jun;Fan, Jialong;Tong, Chunyi;...

通讯作者：

Liu, Bin;Wang, Wei

作者机构：

[Liu, Bin; Fan, Jialong; Zhao, Chuan; Liu, Xuanming; Tong, Chunyi] Hunan Univ, Hunan Prov Key Lab Plant Funct Genom & Dev Regula, Coll Biol, Changsha 410082, Hunan, Peoples R China.

[Wang, Wei; Chen, Yanjiao] Hunan Univ Chinese Med, Sch Pharm, Sinoluxemburg TCM Res Ctr, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.

[Fang, Jun] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Liu, Bin; Wang, Wei] H

Hunan Univ, Hunan Prov Key Lab Plant Funct Genom & Dev Regula, Coll Biol, Changsha 410082, Hunan, Peoples R China.

Hunan Univ Chinese Med, Sch Pharm, Sinoluxemburg TCM Res Ctr, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.

语种：

英文

期刊：

RSC Advances

ISSN：

2046-2069

年：

2017

卷：

期：

页码：

30911-30918

DOI：

10.1039/c7ra04911k

基金类别：

Natural Science Foundation of China [81374062, 85673179, 31672457]; Natural Science Foundation of Hunan Province [h14JJ2049]; Science Foundation for Outstanding Young Scholars of Hunan Province [2015JJ1007]; Fundamental Research Funds for the Central Universities of China [2015JCA03]

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

As a widely used deoxyribonuclease, DNase I is involved in many physiological processes including tumor cell proliferation, metastasis and apoptosis. Furthermore, the level of this enzyme in serum can act as a functional biomarker for the therapeutic monitoring of systemic lupus erythematosus and other diseases. We report here a low cost and sensitive DNase I detecting system based on the single-stranded fluorogenic substrate and nanographene oxide (NGO) and use it for DNase-targeted natural product screening. The system with a detection limit of 0.005 U was then used to evaluate the effect of...

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DNase-targeted natural product screening based on a sensitive and selective DNase i detecting system

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