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Clinical features, diagnosis, and management of dasatinib-induced nephrotic syndrome

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成果类型:
期刊论文
作者:
He, Yang;Fang, Weijin;Li, Zuojun;Wang, Chunjiang
通讯作者:
Wang, C.
作者机构:
[He, Yang] Hunan Univ Chinese Med, Hosp 1, Dept Pharm, Changsha 410007, Hunan, Peoples R China.
[Wang, Chunjiang; Li, Zuojun; Fang, Weijin] Cent South Univ, Xiangya Hosp 3, Dept Pharm, Changsha 410013, Hunan, Peoples R China.
通讯机构:
Department of Pharmacy, The Third Xiangya Hospital, Central South University, Hunan, Changsha, China
语种:
英文
关键词:
Adverse event;Dasatinib;Nephrotic syndrome;Proteinuria;Renal disease
期刊:
Investigational New Drugs
ISSN:
0167-6997
年:
2022
卷:
40
期:
5
页码:
1153-1159
基金类别:
School Science Foundation of Hunan University of Chinese Medicine [2021XJJJ040]
机构署名:
本校为第一机构
院系归属:
第一中医临床学院
药学院
摘要:
Knowledge of dasatinib-induced nephrotic syndrome is largely based on case reports. The clinical features of dasatinib-induced nephrotic syndrome are unknown. We collected case reports of 25 patients with nephrotic syndrome and analyzed their clinical characteristics. Overall, the onset of nephrotic syndrome ranged from 10 days to 5 years after dasatinib administration. Nine patients (36.0%) had clinical symptoms, mainly periorbital edema and lower-extremity edema. Serum albumin ranged from 1.2 g/dL to 3.7 g/dL in 10 patients (38.5%). The 24-h ...

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