期刊论文

中文

世界中西医结合杂志

1673-6613

2011

6

8

663-665

10.3969/j.issn.1673-6613.2011.08.007

湖南省卫生厅中医药专项基金（No.2008025） 长沙市科技局项目（No.K1001061-31）

本校为第一机构

目的 观察舒胃汤对功能性消化不良(FD)大鼠胃排空、胃动素(MTL)和P物质(SP)表达的影响,探讨其可能的作用机制.方法 采用不规则喂养配合夹尾刺激法制作大鼠FD模型,随机分成对照组、模型组、舒胃汤高剂量组、舒胃汤低剂量组、多潘立酮组、木香顺气组六组,连续给药14 d后,用放射免疫法检测血浆SP水平,免疫组化法检测胃窦MTL阳性表达,以酚红法观察胃排空.结果 与对照组相比,模型组胃排空和血浆SP水平显著降低,胃窦组织MTL阳性表达显著降低,差异均有统计学意义(P＜0.05);与模型组相比,舒胃汤高剂量组、木香顺气组及多潘立酮组胃排空和SP水平、MTL表达显著升高,差异均有统计学意义(P＜0.05).结论 舒胃...

Objective To observe the effects of shuwei decoction on gastric emptying,motilin（MTL）and substance P（SP）in the rats with functional dyspepsia（FD）.Methods The irregularly feeding and clip tail stimulation method were adopted to set up FD models.Randomly,6 groups were divided,named a blank group,a model group,a high-dose shuwei decoction group,a low-dose shuwei decoction group,a domperidone group and a muxiang shunqi group.Medication was administered continuously for 14 days.Afterwards,the radioimmunoassay was used to detect plasma SP level...