期刊论文

中文

世界中西医结合杂志

1673-6613

2011

6

9

751-753,789

10.3969/j.issn.1673-6613.2011.09.007

湖南省自然科学基金项目（No.06JJ4038） 湖南省教育厅资助科研项目（No.07c496）

本校为第一机构

目的 探讨IκB分子的上游蛋白激酶(IKKβ)对幽门螺杆菌相关性胃炎(HAG)病理变化的可能机制及灭幽汤在治疗HAG时的影响效应.方法 建立HAG模型,采用幽门螺杆菌(H.pylori)菌液灌胃造模,将造模成功的小鼠按体重随机分为模型组、丽珠得乐组、灭幽汤组.采用免疫组化法检测胃黏膜组织中核转录因子(NF-κB)、IKKβ的蛋白表达情况.HE染色观察胃组织病理变化.结果 灭幽汤组能明显减轻胃组织的炎症反应,能抑制HAG胃组织中NF-κB、IKKβ蛋白的活性.正常对照组小鼠胃黏膜组织细胞内均有少量IKKβ、NF-κB表达.与正常对照组比较,模型组小鼠胃黏膜IKKβ及NF-κB 表达增加(P＜0.05);与模型组比较,灭幽汤组小鼠胃...

Objective To explore the potential mechanism of upstream protein kinasa（IKKβ）of IκB molecules on the pathological change of H.plyori gastritis（HAG）as well as the effect of meiyoutang on HAG.Methods The gastric infusion with H.pylori solution was used to set up HAG model.The successfully modeled mice were divided randomly into a model group,a bismuth potassium citrate tablet group and a mieyoutang group according to the body weight.The immunohistochemical assay was adopted to detect the protein expressions of nuclear transcription factor（...