Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization

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成果类型：

期刊论文

作者：

Hu, Yutong;Kuang, Ming;Song, Hao;Tan, Yang;Zhou, Feng;...

通讯作者：

Pei, Gang;Jiao, LJ

作者机构：

[Hu, Yutong; Song, Hao; Tan, Yang; Zhou, Feng; Jiao, Luojia; Kuang, Ming; Pei, Gang; Pei, G] Hunan Univ Chinese Med, Changsha 410000, Peoples R China.

[Hu, Yutong; Song, Hao; Tan, Yang; Zhou, Feng; Kuang, Ming; Pei, Gang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410000, Peoples R China.

[Hu, Yutong; Song, Hao; Tan, Yang; Zhou, Feng; Kuang, Ming; Pei, Gang] Educ Dept Hunan Prov, Key Lab Modern Res TCM, Changsha 410000, Peoples R China.

通讯机构：

[Jiao, LJ ; Pei, G] H

Hunan Univ Chinese Med, Changsha 410000, Peoples R China.

语种：

英文

关键词：

Astragaloside IV;FoxO1;Glycolysis;Liver injury;Macrophages

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2025

卷：

995

页码：

177353

DOI：

10.1016/j.ejphar.2025.177353

基金类别：

Innovative Research Group Project of the National Natural Science Foundation of China National Natural Science Foundation of China#&#&#82174271

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

Hepatic fibrosis is a late-stage process of many chronic liver diseases. Blocking the fibrosis process will be beneficial to the treatment and recovery of the disease. Hepatic macrophages are a remarkably heterogeneous population of immune cells that play multiple functions in homeostasis and are central to liver fibrosis. Glycolysis-mediated macrophage metabolic reprogramming leads to an increase in the proportion of M1 macrophages and the release of pro-inflammatory cytokines. The present study aimed to investigate the therapeutic effect and mechanism of Astragaloside IV (AS-IV) against carb...

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Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization

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