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An ultrasensitive GSH-specific fluorescent probe unveils celastrol-induced ccRCC ferroptosis

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成果类型:
期刊论文
作者:
Li, Hongfang;Deng, Changfeng;Zhu, Neng;Zhang, Chanjuan;Zeng, Qing;...
通讯作者:
Qin, L.
作者机构:
[Deng, Changfeng; Li, Hongfang; Zhang, Chanjuan; Qin, Li] Hunan Univ Chinese Med, Lab Stem Cell Regulat Chinese Med & Its Applicat, Changsha 410208, Peoples R China.
[Zhu, Neng] Univ Chinese Med, Hosp Hunan 1, Dept Urol, Changsha 410007, Peoples R China.
[Qin, Li] Inst Key Lab Vasc Biol & Translat Med Hunan Prov, Changsha, Peoples R China.
[Qin, Li] Hunan Univ Chinese Med, Hunan Prov Engn Res Ctr Bioact Subst Discovery Tra, Changsha, Peoples R China.
[Qin, Li] Hunan Univ Chinese Med, Sch Pharm, Xueshi Rd & 300, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Qin, L.] S
School of Pharmacy, Xueshi Road & 300, Hunan, China
语种:
英文
关键词:
Glutathione;Fluorescence probe;Celastrol;Clear cell renal cell carcinoma;Ferroptosis
期刊:
Bioorganic Chemistry
ISSN:
0045-2068
年:
2023
卷:
134
页码:
106454
基金类别:
This work was supported by the National Natural Sciences Foundation of China (No. 82274159 , 81973668 and 81774130 ), the National Science Fund of Hunan Province (No. 2022JJ80088 ), the Key Project of the Educational Department of Hunan Province (No. 20A375 , 21A0226 ), Open Fund of the State Key Laboratory Cultivation Base Co-constructed by the Ministry of Traditional Chinese Medicine Powder and Innovative Drug Research in Hunan Province (No. 21PTKF1004 ), the Scientific Research Project of Changsha Science and Technology Bureau (No. kq2004060 ), Key Project of Hunan Provincial Health Commission ( 202213055529 ), the Graduate Research innovation project of Hunan University of Chinese Medicine (No. CX20220792) and First-Class Discipline of Pharmaceutical Science of Hunan .
机构署名:
本校为第一机构
院系归属:
药学院
摘要:
Glutathione (GSH) is closely related to the occurrence and development of tumors. The intracellular GSH levels are abnormally altered when tumor cells undergo programmed cell death. Therefore, real-time monitoring of the dynamic changes of intracellular GSH levels can better enable the early diagnosis of diseases and evaluate the effects of cell death-inducing drugs. In this study, a stable and highly selective fluorescent probe AR has been designed and synthesized for the fluorescence imaging and rapid detection of GSH in vitro and in vivo, as...

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